1.0 2016-05-22 05:03:14 UTC 2026-08-18 16:01:25 UTC Pirfenidone SmallMolecule Pirfenidone is an organic compound with the formula C12H11NO and an average molecular weight of 185.22 g/mol. Pirfenidone belongs to the hydropyridines, a subclass of pyridines and derivatives within the organic compounds. It functions as a biological drug (PMC5096843) and is used as a treatment for pulmonary fibrosis (PMC13006651). At the molecular level, it acts as a modulator of the protein target Transforming growth factor beta-1 proprotein (TGFB1). The compound has been recorded in five sources, including healthcare, pharmaceuticals & veterinary products (specifically immunosuppressants), household cleaning & consumer products (non electric simulated smoking devices), building & construction (ceilings), and electrical & electronic equipment (antennas and electrically stimulated smoking devices). The recorded route of exposure for this substance is oral. pipazetate C12H11NO 185.2218 185.084063979 5-methyl-1-phenyl-1,2-dihydropyridin-2-one pirfenidone 53179-13-8 CC1=CN(C(=O)C=C1)C1=CC=CC=C1 InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3 ISWRGOKTTBVCFA-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Pyridines and derivatives Hydropyridines Pyridinones Azacyclic compounds Benzene and substituted derivatives Dihydropyridines Heteroaromatic compounds Hydrocarbon derivatives Lactams Methylpyridines Organic oxides Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Aromatic heteromonocyclic compound Azacycle Benzenoid Dihydropyridine Heteroaromatic compound Hydrocarbon derivative Lactam Methylpyridine Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Pyridinone Aromatic heteromonocyclic compounds pyridone ring assembly Detected and Not Quantified Pirfenidone Drug Metabolism Action Pathway SMP0143952 Pirfenidone Predicted Metabolism Pathway SMP0174552 logp 2.14 logp 2.00 ALOGPS logs -1.81 ALOGPS solubility 2.89e+00 g/l ALOGPS logp 2.14 ChemAxon pka_strongest_basic -1.2 ChemAxon iupac 5-methyl-1-phenyl-1,2-dihydropyridin-2-one ChemAxon average_mass 185.2218 ChemAxon mono_mass 185.084063979 ChemAxon smiles CC1=CN(C(=O)C=C1)C1=CC=CC=C1 ChemAxon formula C12H11NO ChemAxon inchi InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3 ChemAxon inchikey ISWRGOKTTBVCFA-UHFFFAOYSA-N ChemAxon polar_surface_area 20.31 ChemAxon refractivity 57 ChemAxon polarizability 20.28 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7225acb7c0> DB04951 40632 37115 BE0000984