1.0 2016-05-22 05:04:37 UTC 2026-08-20 06:33:42 UTC Dibucaine SmallMolecule Dibucaine is an organic compound with the formula C20H29N3O2 and an average molecular weight of 343.46 g/mol. Dibucaine belongs to the quinolones and derivatives, a subclass of quinolines and derivatives within the organic compounds. The compound is found in or released from 19 recorded sources across several categories. Within healthcare, pharmaceuticals, and veterinary products, it is associated with anesthetics, local anesthetics, antipruritics, otologicals, and vasoprotectives. It is also found in electrical and electronic equipment, including electric hearing aids, antennas, video games, electrically stimulated smoking devices, and conductors or conductive bodies characterised by the conductive materials. In the category of household cleaning and consumer products, it appears in perfumes within detergents and soaps, cigar cigarettes, non electric simulated smoking devices, pipe accessories, and other smoking requisites. Additionally, it is recorded in food, food processing, and cookware, specifically in food preservation and the preparation of vinegar. Recorded exposure routes for dibucaine include buccal, cutaneous, dental, rectal, and topical. At the molecular level, dibucaine interacts with five recorded protein targets. It acts as an inhibitor of sodium channel protein type 5 subunit alpha (SCN5A) and sodium channel protein type 10 subunit alpha (SCN10A). It also targets calmodulin-1 (CALM1), calmodulin-2 (CALM2), and one other protein. Human Neurotoxin C20H29N3O2 343.4632 343.225977187 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide dibucaine 85-79-0 CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) PUFQVTATUTYEAL-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Quinolines and derivatives Quinolones and derivatives Quinolones and derivatives Alkyl aryl ethers Azacyclic compounds Benzenoids Carboximidic acids Heteroaromatic compounds Hydrocarbon derivatives Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Pyridines and derivatives Trialkylamines Alkyl aryl ether Amine Aromatic heteropolycyclic compound Azacycle Benzenoid Carboximidic acid Carboximidic acid derivative Ether Heteroaromatic compound Hydrocarbon derivative Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Pyridine Quinolone Tertiary aliphatic amine Tertiary amine Aromatic heteropolycyclic compounds aromatic ether monocarboxylic acid amide tertiary amino compound Detected and Not Quantified Dibucaine Action Pathway SMP0000396 Dibucaine Drug Metabolism Pathway SMP0145325 logp 3.7 logp 3.79 ALOGPS logs -3.95 ALOGPS solubility 3.89e-02 g/l ALOGPS logp 3.7 ChemAxon pka_strongest_acidic 14.57 ChemAxon pka_strongest_basic 9.04 ChemAxon iupac 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide ChemAxon average_mass 343.4632 ChemAxon mono_mass 343.225977187 ChemAxon smiles CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC ChemAxon formula C20H29N3O2 ChemAxon inchi InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) ChemAxon inchikey PUFQVTATUTYEAL-UHFFFAOYSA-N ChemAxon polar_surface_area 54.46 ChemAxon refractivity 102.12 ChemAxon polarizability 40.78 ChemAxon rotatable_bond_count 10 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f724401c3a0> DB00527 3025 2917 BE0000197 BE0000177 BE0012563 BE0008705 BE0008706