1.0 2016-05-22 05:05:04 UTC 2026-08-22 06:40:01 UTC Fluocinonide SmallMolecule Fluocinonide is an organic compound with the chemical formula C26H32F2O7 and an average molecular weight of 494.52 g/mol. Fluocinonide belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. The compound is found in or released from 25 recorded sources. Within the healthcare, pharmaceuticals, and veterinary products category, it is used in corticosteroids and combinations of corticosteroids with antibiotics, as well as vasoprotectives. Other sources include food preservation in the food, food processing, and cookware sector. It is also associated with household cleaning and consumer products, such as soap detergents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Additionally, it is found in building and construction materials, including floors, ceilings, roofs, ladders, and sunshades awnings or outside screens. Electrical and electronic equipment sources include hybrid capacitors, electrodes, electrically stimulated smoking devices, conductors or conductive bodies characterised by the conductive materials, and antennas. The recorded exposure route for fluocinonide is topical. The compound interacts with five recorded protein targets, acting as an agonist/modulator of the glucocorticoid receptor (NR3C1). Other protein targets include protein smoothened (SMO), steroid hormone receptor ERR1 (ESRRA), steroid hormone receptor ERR2 (ESRRB), and one other protein. C26H32F2O7 494.5249 494.211609788 2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-8-yl]-2-oxoethyl acetate fluocinonide 356-12-7 [H][C@@]12C[C@@]3([H])[C@]4([H])C[C@]([H])(F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)COC(C)=O InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 WJOHZNCJWYWUJD-IUGZLZTKSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Pregnane steroids Gluco/mineralocorticoids, progestogins and derivatives 1,3-dioxolanes 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-acyloxy ketones Carboxylic acid esters Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Fluorohydrins Halogenated steroids Hydrocarbon derivatives Ketals Monocarboxylic acids and derivatives Organic oxides Organofluorides Oxacyclic compounds Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 20-oxosteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 6-halo-steroid 9-halo-steroid Acetal Alcohol Aliphatic heteropolycyclic compound Alkyl fluoride Alkyl halide Alpha-acyloxy ketone Carbonyl group Carboxylic acid derivative Carboxylic acid ester Cyclic alcohol Cyclic ketone Delta-1,4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Hydroxysteroid Ketal Ketone Meta-dioxolane Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organoheterocyclic compound Organooxygen compound Oxacycle Oxosteroid Progestogin-skeleton Secondary alcohol Aliphatic heteropolycyclic compounds Detected and Not Quantified Fluocinonide Action Pathway SMP0126234 Fluocinonide Drug Metabolism Action Pathway SMP0143473 logp 2.05 logp 2.93 ALOGPS logs -4.47 ALOGPS solubility 1.68e-02 g/l ALOGPS logp 2.05 ChemAxon pka_strongest_acidic 13.55 ChemAxon pka_strongest_basic -3.4 ChemAxon iupac 2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-8-yl]-2-oxoethyl acetate ChemAxon average_mass 494.5249 ChemAxon mono_mass 494.211609788 ChemAxon smiles [H][C@@]12C[C@@]3([H])[C@]4([H])C[C@]([H])(F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)COC(C)=O ChemAxon formula C26H32F2O7 ChemAxon inchi InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 ChemAxon inchikey WJOHZNCJWYWUJD-IUGZLZTKSA-N ChemAxon polar_surface_area 99.13 ChemAxon refractivity 120.56 ChemAxon polarizability 49.12 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 6 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7227585660> DB01047 9642 9265 BE0000794 BE0004659 BE0003722 BE0005001 BE0002088