1.0 2016-05-22 05:07:24 UTC 2026-08-18 19:26:10 UTC Bufexamac SmallMolecule Bufexamac is an organic compound with the chemical formula C12H17NO3 and an average molecular weight of 223.27 g/mol. Bufexamac belongs to the phenylacetamides, a subclass of benzene and substituted derivatives within the organic compounds. This compound is associated with 11 recorded sources. Within the category of healthcare, pharmaceuticals, and veterinary products, it is found in antiinflammatory and antirheumatic products as well as topical products for joint and muscular pain. It is also released from household cleaning and consumer products, specifically non electric simulated smoking devices. Additionally, it is found in electrical and electronic equipment, including amplifiers, discharge lamps, electric switches, electrodes, and electrically stimulated smoking devices, among three other sources. The recorded route of exposure for this substance is topical. At a molecular level, bufexamac interacts with four recorded protein targets. It acts as an inhibitor of Prostaglandin G/H synthase 1 (PTGS1) and Prostaglandin G/H synthase 2 (PTGS2). Furthermore, it targets the proteins Protein deacetylase HDAC6 and Polyamine deacetylase HDAC10. C12H17NO3 223.272 223.120843411 N-hydroxy2-(4-butoxyphenyl)ethanimidic acid jomax 2438-72-4 CCCCOC1=CC=C(CC(O)=NO)C=C1 InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14) MXJWRABVEGLYDG-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Phenylacetamides Phenylacetamides Alkyl aryl ethers Carbonyl compounds Hydrocarbon derivatives Hydroxamic acids Organic oxides Organonitrogen compounds Organopnictogen compounds Phenol ethers Phenoxy compounds Alkyl aryl ether Aromatic homomonocyclic compound Carbonyl group Carboxylic acid derivative Ether Hydrocarbon derivative Hydroxamic acid Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenol ether Phenoxy compound Phenylacetamide Aromatic homomonocyclic compounds aromatic ether hydroxamic acid Detected and Not Quantified Bufexamac Drug Metabolism Action Pathway SMP0144981 logp 1.97 logp 2.50 ALOGPS logs -3.13 ALOGPS solubility 1.67e-01 g/l ALOGPS logp 2.79 ChemAxon pka_strongest_acidic 4.54 ChemAxon pka_strongest_basic 0.39 ChemAxon iupac N-hydroxy2-(4-butoxyphenyl)ethanimidic acid ChemAxon average_mass 223.272 ChemAxon mono_mass 223.120843411 ChemAxon smiles CCCCOC1=CC=C(CC(O)=NO)C=C1 ChemAxon formula C12H17NO3 ChemAxon inchi InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14) ChemAxon inchikey MXJWRABVEGLYDG-UHFFFAOYSA-N ChemAxon polar_surface_area 62.05 ChemAxon refractivity 61.81 ChemAxon polarizability 24.35 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bafed5de0> DB13346 2466 2372 BE0000017 BE0000262 BE0002368 BE0008667