1.0 2016-05-22 05:10:17 UTC 2026-05-14 16:52:11 UTC Rimexolone SmallMolecule Rimexolone is an organic compound with the formula C23H32O4 and an average molecular weight of 372.50 g/mol. Rimexolone belongs to the androstane steroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound is found in or released from healthcare, pharmaceuticals, and veterinary products, specifically as an antiinflammatory agent and corticosteroid. Its recorded route of exposure is ophthalmic. Rimexolone acts on two recorded protein targets, serving as an agonist/modulator of the glucocorticoid receptor (NR3C1) and the steroid hormone receptor ERR1 (ESRRA). C23H32O4 372.505 372.23005951 methyl (1S,2R,10S,11S,13R,14S,15S,17S)-17-hydroxy-2,13,14,15-tetramethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-diene-14-carboxylate rimexolone 49697-38-3 [H][C@@]1(C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]2(C)[C@@]1(C)C(=O)OC InChI=1S/C23H32O4/c1-13-10-17-16-7-6-14-11-15(24)8-9-21(14,2)19(16)18(25)12-22(17,3)23(13,4)20(26)27-5/h8-9,11,13,16-19,25H,6-7,10,12H2,1-5H3/t13-,16+,17+,18+,19-,21+,22+,23-/m1/s1 HJPMTDNGLRNDJA-ZVXCBTRXSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Androstane steroids Androgens and derivatives 11-beta-hydroxysteroids 3-oxo delta-1,4-steroids Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Hydrocarbon derivatives Methyl esters Monocarboxylic acids and derivatives Organic oxides Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Androgen-skeleton Carbonyl group Carboxylic acid derivative Carboxylic acid ester Cyclic alcohol Cyclic ketone Delta-1,4-steroid Hydrocarbon derivative Hydroxysteroid Ketone Methyl ester Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Secondary alcohol Aliphatic homopolycyclic compounds Detected and Not Quantified Rimexolone Action Pathway SMP0126253 Rimexolone Drug Metabolism Action Pathway SMP0143330 logp 4.38 logp 2.95 ALOGPS logs -4.33 ALOGPS solubility 1.73e-02 g/l ALOGPS logp 3.5 ChemAxon pka_strongest_acidic 18.8 ChemAxon pka_strongest_basic -0.21 ChemAxon iupac methyl (1S,2R,10S,11S,13R,14S,15S,17S)-17-hydroxy-2,13,14,15-tetramethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-diene-14-carboxylate ChemAxon average_mass 372.505 ChemAxon mono_mass 372.23005951 ChemAxon smiles [H][C@@]1(C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]2(C)[C@@]1(C)C(=O)OC ChemAxon formula C23H32O4 ChemAxon inchi InChI=1S/C23H32O4/c1-13-10-17-16-7-6-14-11-15(24)8-9-21(14,2)19(16)18(25)12-22(17,3)23(13,4)20(26)27-5/h8-9,11,13,16-19,25H,6-7,10,12H2,1-5H3/t13-,16+,17+,18+,19-,21+,22+,23-/m1/s1 ChemAxon inchikey HJPMTDNGLRNDJA-ZVXCBTRXSA-N ChemAxon polar_surface_area 63.6 ChemAxon refractivity 105.66 ChemAxon polarizability 41.96 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726775a6f8> DB00896 39507 36120 BE0000794 BE0003722