1.0 2016-05-22 05:15:52 UTC 2026-08-21 22:47:53 UTC Desoximetasone SmallMolecule Desoximetasone is an organic compound with the chemical formula C22H29FO4 and an average molecular weight of 376.46 g/mol. Desoximetasone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This substance is categorized under the superclass of lipids and lipid-like molecules. The compound is found in or released from two recorded sources: antennas within electrical and electronic equipment, and corticosteroids used in healthcare, pharmaceuticals, and veterinary products. The recorded route of exposure for this compound is topical. Desoximetasone interacts with four recorded protein targets, acting as an agonist or modulator of the glucocorticoid receptor (NR3C1), the steroid hormone receptor ERR1 (ESRRA), the steroid hormone receptor ERR2 (ESRRB), and the estrogen-related receptor gamma (ESRRG). C22H29FO4 376.4617 376.204987621 (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one desoximetasone 382-67-2 [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1 VWVSBHGCDBMOOT-IIEHVVJPSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Fluorohydrins Gluco/mineralocorticoids, progestogins and derivatives Halogenated steroids Hydrocarbon derivatives Organic oxides Organofluorides Primary alcohols Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 9-halo-steroid Alcohol Aliphatic homopolycyclic compound Alkyl fluoride Alkyl halide Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Aliphatic homopolycyclic compounds 11beta-hydroxy steroid 20-oxo steroid 21-hydroxy steroid 3-oxo-Delta(1),Delta(4)-steroid fluorinated steroid glucocorticoid Detected and Not Quantified Desoximetasone Action Pathway SMP0126224 Desoximetasone Drug Metabolism Action Pathway SMP0142996 logp 2.35 logp 2.13 ALOGPS logs -4.08 ALOGPS solubility 3.10e-02 g/l ALOGPS logp 2.35 ChemAxon pka_strongest_acidic 13.44 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one ChemAxon average_mass 376.4617 ChemAxon mono_mass 376.204987621 ChemAxon smiles [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C ChemAxon formula C22H29FO4 ChemAxon inchi InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1 ChemAxon inchikey VWVSBHGCDBMOOT-IIEHVVJPSA-N ChemAxon polar_surface_area 74.6 ChemAxon refractivity 101.17 ChemAxon polarizability 40.09 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7263609cf8> DB00547 9793 9410 BE0000794 BE0003722 BE0005001 BE0002088