1.0 2016-05-22 05:24:26 UTC 2026-08-22 05:29:40 UTC Hydrocortisone 17-butyrate SmallMolecule Hydrocortisone 17-butyrate belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound, which falls under the superclass of lipids and lipid-like molecules, has the chemical formula C25H36O6 and an average molecular weight of 432.56 g/mol. The substance is found in or released from five recorded sources, including pharmaceuticals & veterinary products such as corticosteroids and combinations with antiseptics, electrical & electronic equipment including fixed capacitors and their manufacture and electrically stimulated smoking devices, and household cleaning & consumer products specifically other smoking requisites. Recorded exposure routes for this compound are cutaneous and topical. Hydrocortisone 17-butyrate interacts with four recorded protein targets. It acts as an agonist or inhibitor of Annexin A1 (ANXA1) and the glucocorticoid receptor (NR3C1). Additionally, it targets 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) and 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1). C25H36O6 432.557 432.251188879 (1S,2R,10S,11S,14R,15S,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl butanoate hydrocortisone 17-butyrate 13609-67-1 [H][C@@]12CC[C@](OC(=O)CCC)(C(=O)CO)[C@@]1(C)C[C@]([H])(O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1 BMCQMVFGOVHVNG-TUFAYURCSA-N Detected and Not Quantified Hydrocortisone butyrate Drug Metabolism Action Pathway SMP0145174 logp 2.86 logp 3.21 ALOGPS logs -4.50 ALOGPS solubility 1.36e-02 g/l ALOGPS logp 2.86 ChemAxon pka_strongest_acidic 13.75 ChemAxon pka_strongest_basic -2.8 ChemAxon iupac (1S,2R,10S,11S,14R,15S,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl butanoate ChemAxon average_mass 432.557 ChemAxon mono_mass 432.251188879 ChemAxon smiles [H][C@@]12CC[C@](OC(=O)CCC)(C(=O)CO)[C@@]1(C)C[C@]([H])(O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C ChemAxon formula C25H36O6 ChemAxon inchi InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1 ChemAxon inchikey BMCQMVFGOVHVNG-TUFAYURCSA-N ChemAxon polar_surface_area 100.9 ChemAxon refractivity 115.78 ChemAxon polarizability 47.79 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7263e3aaa8> DB14540 26133 24344 BE0000422 BE0000794 BE0000131 BE0000051