1.0 2016-05-22 05:24:44 UTC 2026-08-22 08:29:15 UTC Amcinonide SmallMolecule Amcinonide is an organic compound with the chemical formula C28H35FO7. Amcinonide belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. With an average molecular weight of 502.57 g/mol, Amcinonide is a heavy molecule. This compound is found in or released from one recorded source: healthcare, pharmaceuticals, and veterinary products, specifically within the category of corticosteroids. The recorded route of exposure for this substance is topical. In terms of its biological activity, there are five recorded protein targets. Amcinonide acts as an agonist or modulator of the glucocorticoid receptor (NR3C1), annexin A1 (ANXA1), steroid hormone receptor ERR1 (ESRRA), and steroid hormone receptor ERR2 (ESRRB), in addition to one other protein. C28H35FO7 502.5717 502.236681679 2-[(1'S,2'S,4'R,8'S,9'S,11'S,12'R,13'S)-12'-fluoro-11'-hydroxy-9',13'-dimethyl-16'-oxo-5',7'-dioxaspiro[cyclopentane-1,6'-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane]-14',17'-dien-8'-yl]-2-oxoethyl acetate amcinonide 51022-69-6 [H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC1(CCCC1)O2)C(=O)COC(C)=O InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1 ILKJAFIWWBXGDU-MOGDOJJUSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Pregnane steroids Gluco/mineralocorticoids, progestogins and derivatives 1,3-dioxolanes 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-acyloxy ketones Carboxylic acid esters Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Fluorohydrins Halogenated steroids Hydrocarbon derivatives Ketals Monocarboxylic acids and derivatives Organic oxides Organofluorides Oxacyclic compounds Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 20-oxosteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 9-halo-steroid Acetal Alcohol Aliphatic heteropolycyclic compound Alkyl fluoride Alkyl halide Alpha-acyloxy ketone Carbonyl group Carboxylic acid derivative Carboxylic acid ester Cyclic alcohol Cyclic ketone Delta-1,4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Hydroxysteroid Ketal Ketone Meta-dioxolane Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organoheterocyclic compound Organooxygen compound Oxacycle Oxosteroid Progestogin-skeleton Secondary alcohol Aliphatic heteropolycyclic compounds 11beta-hydroxy steroid 20-oxo steroid 3-oxo-Delta(1),Delta(4)-steroid acetate ester corticosteroid fluorinated steroid spiroketal Detected and Not Quantified Amcinonide Action Pathway SMP0126169 Amcinonide Drug Metabolism Action Pathway SMP0142748 logp 3.2 logp 3.16 ALOGPS logs -4.81 ALOGPS solubility 7.74e-03 g/l ALOGPS logp 3.2 ChemAxon pka_strongest_acidic 13.63 ChemAxon pka_strongest_basic -3.4 ChemAxon iupac 2-[(1'S,2'S,4'R,8'S,9'S,11'S,12'R,13'S)-12'-fluoro-11'-hydroxy-9',13'-dimethyl-16'-oxo-5',7'-dioxaspiro[cyclopentane-1,6'-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane]-14',17'-dien-8'-yl]-2-oxoethyl acetate ChemAxon average_mass 502.5717 ChemAxon mono_mass 502.236681679 ChemAxon smiles [H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC1(CCCC1)O2)C(=O)COC(C)=O ChemAxon formula C28H35FO7 ChemAxon inchi InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1 ChemAxon inchikey ILKJAFIWWBXGDU-MOGDOJJUSA-N ChemAxon polar_surface_area 99.13 ChemAxon refractivity 127.88 ChemAxon polarizability 52.23 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 6 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72aba0d3e8> DB00288 39858 36447 BE0000794 BE0000422 BE0003722 BE0005001 BE0002088