1.0 2016-05-22 05:25:40 UTC 2026-08-19 17:04:30 UTC Tegaserod SmallMolecule Tegaserod is an organic compound with the formula C16H23N5O and an average molecular weight of 301.39 g/mol. Tegaserod belongs to the indoles, a subclass of indoles and derivatives within the organic compounds. This compound is utilized in healthcare, pharmaceuticals, and veterinary products as a drug for constipation, with oral exposure being the recorded route. Its pharmacological activity involves four protein targets. Specifically, it acts as a partial agonist of the 5-hydroxytryptamine receptor 4 (HTR4) and functions as an antagonist/antagonist of the 5-hydroxytryptamine receptor 2B (HTR2B), 5-hydroxytryptamine receptor 2C (HTR2C), and 5-hydroxytryptamine receptor 2A (HTR2A). C16H23N5O 301.394 301.190260381 N'-[(E)-[(5-methoxy-1H-indol-3-yl)methylidene]amino]-N-pentylguanidine tegaserod 145158-71-0 CCCCCNC(=N)N\N=C\C1=CNC2=C1C=C(OC)C=C2 InChI=1S/C16H23N5O/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21)/b20-11+ IKBKZGMPCYNSLU-RGVLZGJSSA-N Organic compounds Organoheterocyclic compounds Indoles and derivatives Indoles Indoles Alkyl aryl ethers Anisoles Azacyclic compounds Carboximidamides Guanidines Heteroaromatic compounds Hydrocarbon derivatives Imines Organopnictogen compounds Substituted pyrroles Alkyl aryl ether Anisole Aromatic heteropolycyclic compound Azacycle Benzenoid Carboximidamide Ether Guanidine Heteroaromatic compound Hydrocarbon derivative Imine Indole Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Pyrrole Substituted pyrrole Aromatic heteropolycyclic compounds carboxamidine guanidines hydrazines indoles Detected and Not Quantified Tegaserod Drug Metabolism Action Pathway SMP0143502 logp 2.95 logp 2.76 ALOGPS logs -4.02 ALOGPS solubility 2.88e-02 g/l ALOGPS logp 2.95 ChemAxon pka_strongest_acidic 15.24 ChemAxon pka_strongest_basic 8.5 ChemAxon iupac N'-[(E)-[(5-methoxy-1H-indol-3-yl)methylidene]amino]-N-pentylguanidine ChemAxon average_mass 301.394 ChemAxon mono_mass 301.190260381 ChemAxon smiles CCCCCNC(=N)N\N=C\C1=CNC2=C1C=C(OC)C=C2 ChemAxon formula C16H23N5O ChemAxon inchi InChI=1S/C16H23N5O/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21)/b20-11+ ChemAxon inchikey IKBKZGMPCYNSLU-RGVLZGJSSA-N ChemAxon polar_surface_area 85.29 ChemAxon refractivity 110.25 ChemAxon polarizability 34.96 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 5 ChemAxon donor_count 4 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3baf702780> DB01079 135409453 10609889 BE0000084 BE0000393 BE0000533 BE0000451