1.0 2016-05-22 05:43:55 UTC 2026-05-14 18:19:09 UTC Droxidopa SmallMolecule Droxidopa is an organic compound with the chemical formula C9H11NO5 and an average molecular weight of 213.19 g/mol. Droxidopa belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. This compound is identified in six recorded sources, including healthcare, pharmaceuticals and veterinary products specifically as cardiac stimulants excluding cardiac glycosides, as well as electrical and electronic equipment such as antennas, and building and construction materials including ceilings, fencing, ladders, stairs and ramps. The recorded route of exposure for this substance is oral. In terms of biological activity, there are 10 recorded protein targets for droxidopa. It acts as an agonist or inhibitor of phenylalanine-4-hydroxylase (PAH) as well as the alpha-1A adrenergic receptor (ADRA1A), alpha-1B adrenergic receptor (ADRA1B), and alpha-1D adrenergic receptor (ADRA1D), among 6 other proteins. C9H11NO5 213.189 213.063722458 (2S,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid (2S,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid 23651-95-8 [H][C@@](N)(C(O)=O)[C@@]([H])(O)C1=CC(O)=C(O)C=C1 InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8-/m0/s1 QXWYKJLNLSIPIN-YUMQZZPRSA-N Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Tyrosine and derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Amino acids Aralkylamines Aromatic alcohols Benzene and substituted derivatives Beta hydroxy acids and derivatives Carbonyl compounds Carboxylic acid salts Carboxylic acids Catechols Hydrocarbon derivatives L-alpha-amino acids Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organic salts Organic zwitterions Organopnictogen compounds Phenylalanine and derivatives Phenylpropanoic acids Secondary alcohols 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid 3-phenylpropanoic-acid Alcohol Alpha-amino acid Amine Amino acid Aralkylamine Aromatic alcohol Aromatic homomonocyclic compound Benzenoid Beta-hydroxy acid Carbonyl group Carboxylic acid Carboxylic acid salt Catechol Hydrocarbon derivative Hydroxy acid L-alpha-amino acid Monocarboxylic acid or derivatives Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organic salt Organic zwitterion Organonitrogen compound Organooxygen compound Organopnictogen compound Phenol Phenylalanine or derivatives Primary aliphatic amine Primary amine Secondary alcohol Tyrosine or derivatives Aromatic homomonocyclic compounds Detected and Not Quantified logp -2.7 logp -2.37 ALOGPS logs -1.14 ALOGPS solubility 1.53e+01 g/l ALOGPS logp -2.7 ChemAxon pka_strongest_acidic 1.46 ChemAxon pka_strongest_basic 8.72 ChemAxon iupac (2S,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid ChemAxon average_mass 213.189 ChemAxon mono_mass 213.063722458 ChemAxon smiles [H][C@@](N)(C(O)=O)[C@@]([H])(O)C1=CC(O)=C(O)C=C1 ChemAxon formula C9H11NO5 ChemAxon inchi InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8-/m0/s1 ChemAxon inchikey QXWYKJLNLSIPIN-YUMQZZPRSA-N ChemAxon polar_surface_area 124.01 ChemAxon refractivity 50.29 ChemAxon polarizability 19.44 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 6 ChemAxon donor_count 5 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7221b29388> DB06262 6999030 BE0000753 BE0000501 BE0000575 BE0000715 BE0000289 BE0000572 BE0000342 BE0000172 BE0000694 BE0001012