1.0 2016-05-22 05:44:17 UTC 2026-08-20 04:04:13 UTC Dofetilide SmallMolecule Dofetilide is an organic compound with the chemical formula C19H27N3O5S2 and an average molecular weight of 441.56 g/mol. Dofetilide belongs to the sulfanilides, a subclass of benzene and substituted derivatives within the organic compounds. This compound is identified as being found in or released from six recorded sources. These include healthcare, pharmaceuticals, and veterinary products, specifically class I and III antiarrhythmics. Additionally, it is associated with household cleaning and consumer products, such as cigar cigarettes, non-electric simulated smoking devices, and other smoking requisites, as well as electrical and electronic equipment, including antennas and discharge lamps. The recorded route of exposure for this substance is oral. At the molecular level, dofetilide interacts with three recorded protein targets. It acts as an inhibitor of Potassium channel subfamily K member 2 (KCNK2). Furthermore, it targets the Voltage-gated inwardly rectifying potassium channel KCNH2 and the ATP-sensitive inward rectifier potassium channel 12 (KCNJ12). C19H27N3O5S2 441.565 441.139212369 N-[4-(2-{[2-(4-methanesulfonamidophenyl)ethyl](methyl)amino}ethoxy)phenyl]methanesulfonamide dofetilide 115256-11-6 CN(CCOC1=CC=C(NS(C)(=O)=O)C=C1)CCC1=CC=C(NS(C)(=O)=O)C=C1 InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3 IXTMWRCNAAVVAI-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Sulfanilides Sulfanilides Alkyl aryl ethers Aminosulfonyl compounds Aralkylamines Hydrocarbon derivatives Organic oxides Organic sulfonamides Organopnictogen compounds Organosulfonamides Phenethylamines Phenol ethers Phenoxy compounds Trialkylamines Alkyl aryl ether Amine Aminosulfonyl compound Aralkylamine Aromatic homomonocyclic compound Ether Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid amide Organic sulfonic acid or derivatives Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Phenethylamine Phenol ether Phenoxy compound Sulfanilide Sulfonyl Tertiary aliphatic amine Tertiary amine Aromatic homomonocyclic compounds aromatic ether sulfonamide tertiary amino compound Detected and Not Quantified Dofetilide Action Pathway SMP0126189 Dofetilide Drug Metabolism Action Pathway SMP0142667 logp 0.24 logp 2.17 ALOGPS logs -4.35 ALOGPS solubility 1.98e-02 g/l ALOGPS logp 0.24 ChemAxon pka_strongest_acidic 10.15 ChemAxon pka_strongest_basic 8.99 ChemAxon iupac N-[4-(2-{[2-(4-methanesulfonamidophenyl)ethyl](methyl)amino}ethoxy)phenyl]methanesulfonamide ChemAxon average_mass 441.565 ChemAxon mono_mass 441.139212369 ChemAxon smiles CN(CCOC1=CC=C(NS(C)(=O)=O)C=C1)CCC1=CC=C(NS(C)(=O)=O)C=C1 ChemAxon formula C19H27N3O5S2 ChemAxon inchi InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3 ChemAxon inchikey IXTMWRCNAAVVAI-UHFFFAOYSA-N ChemAxon polar_surface_area 104.81 ChemAxon refractivity 113.27 ChemAxon polarizability 46.03 ChemAxon rotatable_bond_count 9 ChemAxon acceptor_count 6 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f722662ab48> DB00204 71329 BE0000210 BE0000090 BE0001131