1.0 2016-05-22 05:46:58 UTC 2026-08-21 23:10:00 UTC Ganaxolone SmallMolecule Ganaxolone is an organic compound with the chemical formula C22H36O2 and an average molecular weight of 332.53 g/mol. Ganaxolone belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound is found in or released from one recorded source: healthcare, pharmaceuticals & veterinary products, specifically as an antiepileptic. The recorded route of exposure for this substance is oral. Ganaxolone interacts with 16 recorded protein targets, acting as a positive allosteric modulator of Gamma-aminobutyric acid receptor subunit pi (GABRP), Gamma-aminobutyric acid receptor subunit delta (GABRD), Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), and Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1), as well as 12 other proteins. C22H36O2 332.528 332.271530399 1-[(1S,2S,5R,7S,10R,11S,14S,15S)-5-hydroxy-2,5,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]ethan-1-one ganaxolone 38398-32-2 [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@](C)(O)CC[C@]12C InChI=1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1 PGTVWKLGGCQMBR-FLBATMFCSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Pregnane steroids Gluco/mineralocorticoids, progestogins and derivatives 20-oxosteroids 3-alpha-hydroxysteroids Cyclic alcohols and derivatives Hydrocarbon derivatives Ketones Organic oxides Tertiary alcohols 20-oxosteroid 3-alpha-hydroxysteroid 3-hydroxysteroid Alcohol Aliphatic homopolycyclic compound Carbonyl group Cyclic alcohol Hydrocarbon derivative Hydroxysteroid Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Progestogin-skeleton Tertiary alcohol Aliphatic homopolycyclic compounds Detected and Not Quantified Ganaxolone Action Pathway SMP0126153 Ganaxolone Drug Metabolism Action Pathway SMP0143960 logp 4.27 logp 4.37 ALOGPS logs -5.67 ALOGPS solubility 7.12e-04 g/l ALOGPS logp 4.27 ChemAxon pka_strongest_acidic 19.1 ChemAxon pka_strongest_basic -1 ChemAxon iupac 1-[(1S,2S,5R,7S,10R,11S,14S,15S)-5-hydroxy-2,5,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]ethan-1-one ChemAxon average_mass 332.528 ChemAxon mono_mass 332.271530399 ChemAxon smiles [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@](C)(O)CC[C@]12C ChemAxon formula C22H36O2 ChemAxon inchi InChI=1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1 ChemAxon inchikey PGTVWKLGGCQMBR-FLBATMFCSA-N ChemAxon polar_surface_area 37.3 ChemAxon refractivity 97.54 ChemAxon polarizability 40.68 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721fb2cf80> DB05087 6918305 BE0003596 BE0003599 BE0000795 BE0002344 BE0003592 BE0002345 BE0000471 BE0000523 BE0000381 BE0002346 BE0000478 BE0003595 BE0000764 BE0003593 BE0003594 BE0003597