1.0 2016-05-22 05:47:04 UTC 2026-08-18 05:18:26 UTC Rufinamide SmallMolecule Rufinamide is an organic compound with the formula C10H8F2N4O and an average molecular weight of 238.19 g/mol. Rufinamide belongs to the carboxylic acid derivatives, a subclass of carboxylic acids and derivatives within the organic compounds. This compound is found in or released from two recorded sources: household cleaning and consumer products, specifically non electric simulated smoking devices, and healthcare, pharmaceuticals and veterinary products, specifically antiepileptics. The recorded exposure route for this substance is oral. Regarding its biological activity, there are two recorded protein targets for rufinamide; it acts as an inhibitor or modulator of the sodium channel protein type 9 subunit alpha (SCN9A) and the metabotropic glutamate receptor 5 (GRM5). Human Neurotoxin C10H8F2N4O 238.1935 238.066617308 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide rufinamide 106308-44-5 NC(=O)C1=CN(CC2=C(F)C=CC=C2F)N=N1 InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17) POGQSBRIGCQNEG-UHFFFAOYSA-N Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives 2-heteroaryl carboxamides Aryl fluorides Azacyclic compounds Fluorobenzenes Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organofluorides Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Primary carboxylic acid amides Triazoles Vinylogous amides 1,2,3-triazole 2-heteroaryl carboxamide Aromatic heteromonocyclic compound Aryl fluoride Aryl halide Azacycle Azole Benzenoid Fluorobenzene Halobenzene Heteroaromatic compound Hydrocarbon derivative Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary carboxylic acid amide Vinylogous amide Aromatic heteromonocyclic compounds Detected and Not Quantified Rufinamide Action Pathway SMP0126280 Rufinamide Drug Metabolism Action Pathway SMP0144004 logp 1.27 logp 0.95 ALOGPS logs -2.57 ALOGPS solubility 6.42e-01 g/l ALOGPS logp 1.27 ChemAxon pka_strongest_acidic 12.69 ChemAxon pka_strongest_basic -1.1 ChemAxon iupac 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide ChemAxon average_mass 238.1935 ChemAxon mono_mass 238.066617308 ChemAxon smiles NC(=O)C1=CN(CC2=C(F)C=CC=C2F)N=N1 ChemAxon formula C10H8F2N4O ChemAxon inchi InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17) ChemAxon inchikey POGQSBRIGCQNEG-UHFFFAOYSA-N ChemAxon polar_surface_area 73.8 ChemAxon refractivity 67.07 ChemAxon polarizability 20.42 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72244232c0> DB06201 129228 114471 BE0001192 BE0001143