1.0 2016-05-22 05:52:22 UTC 2026-08-18 23:27:02 UTC Lenalidomide SmallMolecule Lenalidomide (C13H13N3O3) is an organic compound with an average molecular weight of 259.26 g/mol. Lenalidomide belongs to the isoindolines, a subclass of isoindoles and derivatives within the organic compounds. It functions as a drug (PMC4695140) and an anti-inflammatory agent (PMC3732931). The compound acts as an antagonist, inhibitor, or negative modulator of Protein cereblon (CRBN), Tumor necrosis factor ligand superfamily member 11 (TNFSF11), Prostaglandin G/H synthase 2 (PTGS2), Cadherin-5 (CDH5), and one other protein. Oral exposure is a recorded route for this compound, which is found in sources including healthcare, pharmaceuticals and veterinary products (immunosuppressants), household cleaning and consumer products (non electric simulated smoking devices), food, food processing and cookware (preparation of wine or sparkling wine), and electrical and electronic equipment (antennas, electric hearing aids). Lenalidomide is used in the treatment of anemia (PMC3977019, PMC4706836), B-cell lymphoma (PMC11743790), acute myeloid leukemia (PMC3128214), neuropathy (PMC7109734), and multiple myeloma (PMC10022849, PMC10040899, PMC10184122, PMC10216254, PMC10649824, PMC11172882, PMC11201495, PMC11219377). It has therapeutic effects on fatigue (PMC4408989) and multiple myeloma (PMC3496085, PMC4889030, PMC5217191, PMC5930136, PMC6410697, PMC7368820). Associated health effects include fatigue (PMC11219377, PMC12405678, PMC3674591, PMC3699390, PMC5215577, PMC6290473, PMC8171498, PMC8212249), neutropenia (PMC10230432, PMC10651865, PMC11219377, PMC11404760, PMC12052864, PMC12399965, PMC12405678, PMC12553274, PMC12801173), thrombocytopenia (PMC10651865, PMC12052864, PMC2361627, PMC3670754, PMC3674591, PMC3699390, PMC4232868, PMC4559079), diarrhea (PMC10828760, PMC12405678, PMC12801173, PMC4559079, PMC4753325, PMC6290473, PMC7271593), and thrombosis (PMC10519171, PMC10651865, PMC12946163, PMC13187128, PMC3674591, PMC4753325). Other associations include rash (PMC10230432, PMC10519171, PMC12405678, PMC4436674, PMC5215577, PMC6290473, PMC8171498, PMC8212249), pneumonia (PMC3227886, PMC3699390, PMC5679834, PMC8212249), hypokalemia (PMC5930136, PMC6290473, PMC8212249), bleeding (PMC10230432), neuropathy (PMC11219377), neuropathic pain (PMC4559079), confusion (PMC5930136), hypertension (PMC12946163), congestive heart failure (PMC12946163), cough (PMC8171498), bronchitis (PMC8171498), and renal failure (PMC11554676). The compound is elevated in the blood during renal insufficiency (PMC3673285). Human Neurotoxin Lenalidomid C13H13N3O3 259.2606 259.095691297 3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione lenalidomide 191732-72-6 NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) GOTYRUGSSMKFNF-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolines Isoindolones Alpha amino acids and derivatives Azacyclic compounds Benzenoids Carbonyl compounds Delta lactams Dicarboximides Hydrocarbon derivatives Isoindoles N-unsubstituted carboxylic acid imides Organic oxides Organopnictogen compounds Piperidinediones Primary amines Tertiary carboxylic acid amides Alpha-amino acid or derivatives Amine Amino acid or derivatives Aromatic heteropolycyclic compound Azacycle Benzenoid Carbonyl group Carboxamide group Carboxylic acid derivative Carboxylic acid imide Carboxylic acid imide, n-unsubstituted Delta-lactam Dicarboximide Hydrocarbon derivative Isoindole Isoindolone Lactam Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Piperidine Piperidinedione Piperidinone Primary amine Tertiary carboxylic acid amide Aromatic heteropolycyclic compounds aromatic amine dicarboximide isoindoles piperidones Detected and Not Quantified Lenalidomide Drug Metabolism Action Pathway SMP0142934 Lenalidomide Predicted Metabolism Pathway SMP0174656 logp -0.71 logp -0.43 ALOGPS logs -2.05 ALOGPS solubility 2.33e+00 g/l ALOGPS logp -0.71 ChemAxon pka_strongest_acidic 11.61 ChemAxon pka_strongest_basic 2.31 ChemAxon iupac 3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione ChemAxon average_mass 259.2606 ChemAxon mono_mass 259.095691297 ChemAxon smiles NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O ChemAxon formula C13H13N3O3 ChemAxon inchi InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) ChemAxon inchikey GOTYRUGSSMKFNF-UHFFFAOYSA-N ChemAxon polar_surface_area 92.5 ChemAxon refractivity 68.3 ChemAxon polarizability 25.55 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f727a9b0200> DB00480 216326 187515 BE0000262 BE0003517 BE0003403 BE0004755 BE0000704