1.0 2016-05-22 05:56:07 UTC 2026-05-14 16:59:11 UTC Desonide SmallMolecule Desonide is an organic compound with the chemical formula C24H32O6 and an average molecular weight of 416.51 g/mol. Desonide belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound is found in or released from six recorded sources. These include healthcare, pharmaceuticals, and veterinary products, specifically as antiinflammatory agents, corticosteroids, and corticosteroids in combinations with antiseptics. It is also associated with household cleaning and consumer products, such as other smoking requisites and non electric simulated smoking devices, as well as building and construction materials, specifically floors. The recorded route of exposure for this substance is topical. At the molecular level, desonide interacts with four recorded protein targets. It acts as an agonist or modulator of the glucocorticoid receptor (NR3C1). Additionally, it targets several steroid hormone receptors, including the estrogen-related receptor gamma (ESRRG), steroid hormone receptor ERR1 (ESRRA), and steroid hormone receptor ERR2 (ESRRB). C24H32O6 416.5073 416.219888756 (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-16-one desonide 638-94-8 [H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1 WBGKWQHBNHJJPZ-LECWWXJVSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 1,3-dioxolanes 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Ketals Organic oxides Oxacyclic compounds Primary alcohols Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid Acetal Alcohol Aliphatic heteropolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Hydrocarbon derivative Ketal Ketone Meta-dioxolane Organic oxide Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Aliphatic heteropolycyclic compounds 11beta-hydroxy steroid 20-oxo steroid 21-hydroxy steroid 3-oxo-Delta(1),Delta(4)-steroid corticosteroid cyclic ketal Detected and Not Quantified Desonide Action Pathway SMP0126223 Desonide Drug Metabolism Action Pathway SMP0143675 logp 1.9 logp 2.31 ALOGPS logs -3.85 ALOGPS solubility 5.94e-02 g/l ALOGPS logp 1.9 ChemAxon pka_strongest_acidic 13.74 ChemAxon pka_strongest_basic -2.9 ChemAxon iupac (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-16-one ChemAxon average_mass 416.5073 ChemAxon mono_mass 416.219888756 ChemAxon smiles [H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO ChemAxon formula C24H32O6 ChemAxon inchi InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1 ChemAxon inchikey WBGKWQHBNHJJPZ-LECWWXJVSA-N ChemAxon polar_surface_area 93.06 ChemAxon refractivity 112.06 ChemAxon polarizability 44.77 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 6 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72a02b7ef0> DB01260 5311066 4470603 BE0000794 BE0003722 BE0005001 BE0002088