1.0 2016-05-22 05:56:58 UTC 2026-08-21 21:21:09 UTC Tadalafil SmallMolecule Tadalafil is an organic compound with the formula C22H19N3O4 and an average molecular weight of 389.40 g/mol. Tadalafil belongs to the pyridoindoles, a subclass of indoles and derivatives within the organic compounds. It is classified as an organoheterocyclic compound. The substance has three recorded protein targets, acting as an inhibitor of cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), as well as targeting dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A) and retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6G). Regarding health effects, it is associated with a decrease in hypotension (PMC12454544). Tadalafil is found in or released from 35 recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is used in urologicals, antihypertensives, and drugs used in benign prostatic hypertrophy. Other sources include building and construction materials such as floors, ceilings, roofs, fencing, and stairs and ramps. It is also associated with food, food processing, and cookware, specifically the treatment of hops and the processing of meats and fish, as well as the preparation of sparkling wine or wine. Household cleaning and consumer products include pipe accessories, tobacco pipes, other smoking requisites, and non electric simulated smoking devices. Additionally, it is found in electrical and electronic equipment, including antennas, coils, discharge lamps, amplifiers, and colour television systems. The recorded exposure route for this compound is oral. Human Neurotoxin C22H19N3O4 389.404 389.137556111 (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraene-4,7-dione tadalafil 171596-29-5 [H][C@]12CC3=C(NC4=CC=CC=C34)[C@H](N1C(=O)CN(C)C2=O)C1=CC2=C(OCO2)C=C1 InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 WOXKDUGGOYFFRN-IIBYNOLFSA-N Organic compounds Organoheterocyclic compounds Indoles and derivatives Pyridoindoles Beta carbolines 2,5-dioxopiperazines 3-alkylindoles Acetals Alpha amino acids and derivatives Azacyclic compounds Benzenoids Benzodioxoles Carbonyl compounds Heteroaromatic compounds Hydrocarbon derivatives Lactams N-methylpiperazines Organic oxides Organonitrogen compounds Organopnictogen compounds Oxacyclic compounds Pyrroles Tertiary carboxylic acid amides 1,4-diazinane 2,5-dioxopiperazine 3-alkylindole Acetal Alpha-amino acid or derivatives Aromatic heteropolycyclic compound Azacycle Benzenoid Benzodioxole Beta-carboline Carbonyl group Carboxamide group Carboxylic acid derivative Dioxopiperazine Heteroaromatic compound Hydrocarbon derivative Indole Lactam N-alkylpiperazine N-methylpiperazine Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Piperazine Pyrrole Tertiary carboxylic acid amide Aromatic heteropolycyclic compounds benzodioxoles pyrazinopyridoindole Detected and Not Quantified Tadalafil Drug Metabolism Action Pathway SMP0143258 logp 1.64 logp 2.36 ALOGPS logs -3.19 ALOGPS solubility 2.50e-01 g/l ALOGPS logp 1.64 ChemAxon pka_strongest_acidic 15.17 ChemAxon pka_strongest_basic -4.2 ChemAxon iupac (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraene-4,7-dione ChemAxon average_mass 389.404 ChemAxon mono_mass 389.137556111 ChemAxon smiles [H][C@]12CC3=C(NC4=CC=CC=C34)[C@H](N1C(=O)CN(C)C2=O)C1=CC2=C(OCO2)C=C1 ChemAxon formula C22H19N3O4 ChemAxon inchi InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 ChemAxon inchikey WOXKDUGGOYFFRN-IIBYNOLFSA-N ChemAxon polar_surface_area 74.87 ChemAxon refractivity 104.08 ChemAxon polarizability 40.92 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf32c9760> DB00820 110635 99301 BE0000182 BE0003558 BE0003556