1.0 2016-05-22 06:16:13 UTC 2026-08-21 22:47:54 UTC Fluorometholone SmallMolecule Fluorometholone is an organic compound with the chemical formula C22H29FO4 and an average molecular weight of 376.46 g/mol. Fluorometholone belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound acts as an agonist of the Glucocorticoid receptor (NR3C1). It has been recorded in 30 different sources. Within healthcare, pharmaceuticals, and veterinary products, it is utilized in corticosteroids, corticosteroids combined with antibiotics, anti-acne preparations, antiinflammatory agents, and vasoprotectives. It is also associated with household cleaning and consumer products, including tobacco smoke filters, perfumes within detergents and soaps, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. Additionally, it is found in food, food processing, and cookware contexts, specifically in the preparation of vinegar, the preparation of wine or sparkling wine, food preservation, and fermentation processes for beer. Other recorded sources include electrical and electronic equipment, such as antennas, amplifiers, conductors or conductive bodies characterised by the conductive materials, electrically stimulated smoking devices, and electric hearing aids. The recorded exposure route for this compound is ophthalmic. (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one C22H29FO4 376.4617 376.204987621 (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one fluorometholone 426-13-1 [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 FAOZLTXFLGPHNG-KNAQIMQKSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Pregnane steroids Gluco/mineralocorticoids, progestogins and derivatives 11-beta-hydroxysteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Fluorohydrins Halogenated steroids Hydrocarbon derivatives Organic oxides Organofluorides Secondary alcohols Tertiary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 17-hydroxysteroid 20-oxosteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 9-halo-steroid Alcohol Aliphatic homopolycyclic compound Alkyl fluoride Alkyl halide Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Hydroxysteroid Ketone Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organooxygen compound Oxosteroid Progestogin-skeleton Secondary alcohol Tertiary alcohol Aliphatic homopolycyclic compounds 11beta-hydroxy steroid 17alpha-hydroxy steroid 20-oxo steroid 3-oxo-Delta(1),Delta(4)-steroid fluorinated steroid glucocorticoid Detected and Not Quantified Fluorometholone Action Pathway SMP0126255 Fluorometholone Drug Metabolism Action Pathway SMP0142783 Fluorometholone Predicted Metabolism Pathway SMP0174582 logp 2.42 logp 2.34 ALOGPS logs -4.36 ALOGPS solubility 1.66e-02 g/l ALOGPS logp 2.42 ChemAxon pka_strongest_acidic 12.65 ChemAxon pka_strongest_basic -3.4 ChemAxon iupac (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one ChemAxon average_mass 376.4617 ChemAxon mono_mass 376.204987621 ChemAxon smiles [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C ChemAxon formula C22H29FO4 ChemAxon inchi InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 ChemAxon inchikey FAOZLTXFLGPHNG-KNAQIMQKSA-N ChemAxon polar_surface_area 74.6 ChemAxon refractivity 100.87 ChemAxon polarizability 40.05 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f727a2051e0> DB00324 9878 9494 BE0000794