1.0 2016-05-22 06:36:05 UTC 2026-08-19 09:47:43 UTC Nepafenac SmallMolecule Nepafenac is an organic compound with the formula C15H14N2O2 and an average molecular weight of 254.28 g/mol. Nepafenac belongs to the benzophenones, a subclass of benzene and substituted derivatives within the organic compounds. It is recorded as being found in or released from two sources: healthcare, pharmaceuticals & veterinary products (specifically antiinflammatory agents) and household cleaning & consumer products (specifically non electric simulated smoking devices). The recorded exposure route for this compound is ophthalmic. At the molecular level, nepafenac interacts with two recorded protein targets. It acts as an inhibitor of Prostaglandin G/H synthase 1 (PTGS1) and Prostaglandin G/H synthase 2 (PTGS2). C15H14N2O2 254.2839 254.105527702 2-(2-amino-3-benzoylphenyl)acetamide nepafenac 78281-72-8 NC(=O)CC1=CC=CC(C(=O)C2=CC=CC=C2)=C1N InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) QEFAQIPZVLVERP-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzophenones Benzophenones Amino acids and derivatives Aniline and substituted anilines Aryl-phenylketones Benzoyl derivatives Diphenylmethanes Hydrocarbon derivatives Organic oxides Organopnictogen compounds Phenylacetamides Primary amines Primary carboxylic acid amides Vinylogous amides Amine Amino acid or derivatives Aniline or substituted anilines Aromatic homomonocyclic compound Aryl ketone Aryl-phenylketone Benzophenone Benzoyl Carbonyl group Carboxamide group Carboxylic acid derivative Diphenylmethane Hydrocarbon derivative Ketone Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenylacetamide Primary amine Primary carboxylic acid amide Vinylogous amide Aromatic homomonocyclic compounds monocarboxylic acid amide Detected and Not Quantified Nepafenac Action Pathway SMP0000702 Nepafenac NSAID Action Pathway SMP0124581 Nepafenac Drug Metabolism SMP0130823 Nepafenac Drug Metabolism Action Pathway SMP0144138 logp 2.08 logp 1.53 ALOGPS logs -4.11 ALOGPS solubility 1.97e-02 g/l ALOGPS logp 2.08 ChemAxon pka_strongest_acidic 15.82 ChemAxon pka_strongest_basic 1.83 ChemAxon iupac 2-(2-amino-3-benzoylphenyl)acetamide ChemAxon average_mass 254.2839 ChemAxon mono_mass 254.105527702 ChemAxon smiles NC(=O)CC1=CC=CC(C(=O)C2=CC=CC=C2)=C1N ChemAxon formula C15H14N2O2 ChemAxon inchi InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) ChemAxon inchikey QEFAQIPZVLVERP-UHFFFAOYSA-N ChemAxon polar_surface_area 86.18 ChemAxon refractivity 74.46 ChemAxon polarizability 26.63 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7273a66d68> DB06802 151075 133160 BE0000017 BE0000262