1.0 2016-05-22 06:39:23 UTC 2026-08-21 18:55:53 UTC Pazopanib SmallMolecule Pazopanib is an organic compound with the chemical formula C21H23N7O2S and an average molecular weight of 437.52 g/mol. Pazopanib belongs to the amines, a subclass of organonitrogen compounds within the organic compounds. This compound is recorded as being found in or released from three sources: electrical and electronic equipment, specifically antennas and electric hearing aids, as well as healthcare, pharmaceuticals, and veterinary products, where it is used as an antineoplastic agent. The recorded route of exposure for this substance is oral. In terms of biological activity, pazopanib acts on ten recorded protein targets. It functions as an inhibitor of Vascular endothelial growth factor receptor 1 (FLT1), Vascular endothelial growth factor receptor 2 (KDR), and Vascular endothelial growth factor receptor 3 (FLT4). Additionally, it inhibits Platelet-derived growth factor receptor alpha (PDGFRA) and six other proteins. Human Neurotoxin C21H23N7O2S 437.518 437.163393705 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide pazopanib 444731-52-6 CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=CC=NC(NC2=CC=C(C)C(=C2)S(N)(=O)=O)=N1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N Organic compounds Organic nitrogen compounds Organonitrogen compounds Amines Alkyldiarylamines Aminopyrimidines and derivatives Aminosulfonyl compounds Aniline and substituted anilines Azacyclic compounds Benzenesulfonamides Benzenesulfonyl compounds Heteroaromatic compounds Hydrocarbon derivatives Imidolactams Indazoles Organic oxides Organopnictogen compounds Organosulfonamides Pyrazoles Secondary amines Toluenes Alkyldiarylamine Aminopyrimidine Aminosulfonyl compound Aniline or substituted anilines Aromatic heteropolycyclic compound Azacycle Azole Benzenesulfonamide Benzenesulfonyl group Benzenoid Benzopyrazole Heteroaromatic compound Hydrocarbon derivative Imidolactam Indazole Monocyclic benzene moiety Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organoheterocyclic compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Pyrazole Pyrimidine Secondary amine Sulfonyl Toluene Aromatic heteropolycyclic compounds aminopyrimidine indazoles sulfonamide Detected and Not Quantified Pazopanib Action Pathway SMP0126899 Pazopanib Drug Metabolism Action Pathway SMP0144050 logp 3.55 logp 3.59 ALOGPS logs -4.00 ALOGPS solubility 4.33e-02 g/l ALOGPS logp 3.55 ChemAxon pka_strongest_acidic 10.41 ChemAxon pka_strongest_basic 5.07 ChemAxon iupac 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide ChemAxon average_mass 437.518 ChemAxon mono_mass 437.163393705 ChemAxon smiles CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=CC=NC(NC2=CC=C(C)C(=C2)S(N)(=O)=O)=N1 ChemAxon formula C21H23N7O2S ChemAxon inchi InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) ChemAxon inchikey CUIHSIWYWATEQL-UHFFFAOYSA-N ChemAxon polar_surface_area 119.03 ChemAxon refractivity 132.18 ChemAxon polarizability 45.41 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 7 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf8105000> DB06589 10113978 BE0000029 BE0000369 BE0000023 BE0000852 BE0000205 BE0000453 BE0002133 BE0001341 BE0000689 BE0004714