1.0 2016-05-22 06:58:55 UTC 2026-08-20 03:09:48 UTC Prazosin SmallMolecule Prazosin is an organic compound with the chemical formula C19H21N5O4 and an average molecular weight of 383.40 g/mol. Prazosin belongs to the piperazines, a subclass of diazinanes within the organic compounds. This compound is associated with 14 recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is used as an antihypertensive. It is also found in food preservation and various household cleaning and consumer products, including tobacco smoke filters, perfumes within detergents and soaps, non electric simulated smoking devices, cigar cigarettes, and other smoking requisites. Additionally, it is released from electrical and electronic equipment, specifically electrodes, antennas, coils, conductors or conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices. The recorded exposure route for this substance is oral. At the molecular level, Prazosin interacts with six recorded protein targets. It acts as an antagonist, binder, or inhibitor of the Alpha-1A adrenergic receptor (ADRA1A), the Alpha-1B adrenergic receptor (ADRA1B), and the Alpha-1D adrenergic receptor (ADRA1D). Furthermore, it targets the voltage-gated inwardly rectifying potassium channel KCNH2 and two other proteins. C19H21N5O4 383.4011 383.159354185 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine prazosin 19216-56-9 COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1=CC=CO1 InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) IENZQIKPVFGBNW-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Diazinanes Piperazines N-arylpiperazines 2-heteroaryl carboxamides Alkyl aryl ethers Amino acids and derivatives Aminopyrimidines and derivatives Anisoles Azacyclic compounds Dialkylarylamines Furoic acid and derivatives Heteroaromatic compounds Hydrocarbon derivatives Imidolactams Organic oxides Organopnictogen compounds Oxacyclic compounds Primary amines Quinazolinamines Tertiary carboxylic acid amides 2-heteroaryl carboxamide Alkyl aryl ether Amine Amino acid or derivatives Aminopyrimidine Anisole Aromatic heteropolycyclic compound Azacycle Benzenoid Carboxamide group Carboxylic acid derivative Dialkylarylamine Diazanaphthalene Ether Furan Furoic acid or derivatives Heteroaromatic compound Hydrocarbon derivative Imidolactam N-arylpiperazine Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Primary amine Pyrimidine Quinazolinamine Quinazoline Tertiary carboxylic acid amide Aromatic heteropolycyclic compounds aromatic ether furans monocarboxylic acid amide piperazines quinazolines Detected and Not Quantified Prazosin Action Pathway SMP0125086 Prazosin Drug Metabolism Action Pathway SMP0142913 Prazosin Predicted Metabolism Pathway SMP0174674 logp 1.65 logp 1.93 ALOGPS logs -2.74 ALOGPS solubility 6.93e-01 g/l ALOGPS logp 1.65 ChemAxon pka_strongest_basic 7.24 ChemAxon iupac 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine ChemAxon average_mass 383.4011 ChemAxon mono_mass 383.159354185 ChemAxon smiles COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1=CC=CO1 ChemAxon formula C19H21N5O4 ChemAxon inchi InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) ChemAxon inchikey IENZQIKPVFGBNW-UHFFFAOYSA-N ChemAxon polar_surface_area 106.95 ChemAxon refractivity 104.5 ChemAxon polarizability 40.49 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 7 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bd0044d00> DB00457 4893 4724 BE0000501 BE0000575 BE0000715 BE0000090 BE0000289 BE0000572