1.0 2016-05-22 07:18:41 UTC 2026-08-20 01:08:22 UTC Prucalopride SmallMolecule Prucalopride is an organic compound with the formula C18H26ClN3O3 and an average molecular weight of 367.87 g/mol. Prucalopride belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. It acts as an agonist of the protein target 5-hydroxytryptamine receptor 4 (HTR4). The compound is found in or released from two recorded sources: household cleaning and consumer products, specifically non electric simulated smoking devices, and healthcare, pharmaceuticals and veterinary products, where it is used as a drug for constipation. The recorded route of exposure for this substance is oral. C18H26ClN3O3 367.87 367.1662694 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide prucalopride 179474-81-8 COCCCN1CCC(CC1)NC(=O)C1=C2OCCC2=C(N)C(Cl)=C1 InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23) ZPMNHBXQOOVQJL-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Aminobenzamides Alkyl aryl ethers Amino acids and derivatives Aryl chlorides Azacyclic compounds Coumarans Dialkyl ethers Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds Oxacyclic compounds Piperidines Primary amines Secondary carboxylic acid amides Trialkylamines Alkyl aryl ether Amine Amino acid or derivatives Aminobenzamide Aromatic heteropolycyclic compound Aryl chloride Aryl halide Azacycle Carboxamide group Carboxylic acid derivative Coumaran Dialkyl ether Ether Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organochloride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Piperidine Primary amine Secondary carboxylic acid amide Tertiary aliphatic amine Tertiary amine Aromatic heteropolycyclic compounds Detected and Not Quantified Prucalopride Action Pathway SMP0127044 Prucalopride Drug Metabolism Action Pathway SMP0144049 logp 0.74 logp 2.09 ALOGPS logs -3.46 ALOGPS solubility 1.29e-01 g/l ALOGPS logp 0.74 ChemAxon pka_strongest_acidic 14.64 ChemAxon pka_strongest_basic 8.98 ChemAxon iupac 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide ChemAxon average_mass 367.87 ChemAxon mono_mass 367.1662694 ChemAxon smiles COCCCN1CCC(CC1)NC(=O)C1=C2OCCC2=C(N)C(Cl)=C1 ChemAxon formula C18H26ClN3O3 ChemAxon inchi InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23) ChemAxon inchikey ZPMNHBXQOOVQJL-UHFFFAOYSA-N ChemAxon polar_surface_area 76.82 ChemAxon refractivity 100.67 ChemAxon polarizability 39.08 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bcfbb1c20> DB06480 3052762 2314539 BE0000084