1.0 2016-05-22 07:18:56 UTC 2026-08-22 08:31:34 UTC Bilastine SmallMolecule Bilastine belongs to the benzimidazoles, a class of organoheterocyclic compounds within the organic compounds. It has the chemical formula $\text{C}_{28}\text{H}_{37}\text{N}_3\text{O}_3$ and an average molecular weight of 463.62 g/mol. This compound acts as an antagonist of the Histamine H1 receptor (HRH1). Bilastine is found in or released from four recorded sources: healthcare, pharmaceuticals & veterinary products (specifically antihistamines, decongestants and antiallergics), electrical & electronic equipment (auxiliary devices), and household cleaning & consumer products (non electric simulated smoking devices). The recorded route of exposure for this compound is oral. C28H37N3O3 463.622 463.283492063 2-[4-(2-{4-[1-(2-ethoxyethyl)-1H-1,3-benzodiazol-2-yl]piperidin-1-yl}ethyl)phenyl]-2-methylpropanoic acid bilastine 202189-78-4 CCOCCN1C(=NC2=CC=CC=C12)C1CCN(CCC2=CC=C(C=C2)C(C)(C)C(O)=O)CC1 InChI=1S/C28H37N3O3/c1-4-34-20-19-31-25-8-6-5-7-24(25)29-26(31)22-14-17-30(18-15-22)16-13-21-9-11-23(12-10-21)28(2,3)27(32)33/h5-12,22H,4,13-20H2,1-3H3,(H,32,33) ACCMWZWAEFYUGZ-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Benzimidazoles Benzimidazoles Amino acids Aralkylamines Azacyclic compounds Carbonyl compounds Carboxylic acids Dialkyl ethers Heteroaromatic compounds Hydrocarbon derivatives Monocarboxylic acids and derivatives N-substituted imidazoles Organic oxides Organopnictogen compounds Phenethylamines Phenylpropanes Piperidines Trialkylamines Amine Amino acid Amino acid or derivatives Aralkylamine Aromatic heteropolycyclic compound Azacycle Azole Benzenoid Benzimidazole Carbonyl group Carboxylic acid Carboxylic acid derivative Dialkyl ether Ether Heteroaromatic compound Hydrocarbon derivative Imidazole Monocarboxylic acid or derivatives Monocyclic benzene moiety N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenethylamine Phenylpropane Piperidine Tertiary aliphatic amine Tertiary amine Aromatic heteropolycyclic compounds Detected and Not Quantified Bilastine H1-Antihistamine Action SMP0060170 Bilastine Drug Metabolism Action Pathway SMP0144726 Bilastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway SMP0174932 Bilastine H1-Antihistamine Blood Vessel Constriction Action Pathway SMP0175024 Bilastine H1-Antihistamine Immune Response Action Pathway SMP0175116 logp 2.41 logp 5.02 ALOGPS logs -5.36 ALOGPS solubility 2.03e-03 g/l ALOGPS logp 2.41 ChemAxon pka_strongest_acidic 4.06 ChemAxon pka_strongest_basic 9.43 ChemAxon iupac 2-[4-(2-{4-[1-(2-ethoxyethyl)-1H-1,3-benzodiazol-2-yl]piperidin-1-yl}ethyl)phenyl]-2-methylpropanoic acid ChemAxon average_mass 463.622 ChemAxon mono_mass 463.283492063 ChemAxon smiles CCOCCN1C(=NC2=CC=CC=C12)C1CCN(CCC2=CC=C(C=C2)C(C)(C)C(O)=O)CC1 ChemAxon formula C28H37N3O3 ChemAxon inchi InChI=1S/C28H37N3O3/c1-4-34-20-19-31-25-8-6-5-7-24(25)29-26(31)22-14-17-30(18-15-22)16-13-21-9-11-23(12-10-21)28(2,3)27(32)33/h5-12,22H,4,13-20H2,1-3H3,(H,32,33) ChemAxon inchikey ACCMWZWAEFYUGZ-UHFFFAOYSA-N ChemAxon polar_surface_area 67.59 ChemAxon refractivity 135.58 ChemAxon polarizability 54.96 ChemAxon rotatable_bond_count 10 ChemAxon acceptor_count 5 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72678f55a8> DB11591 185460 79591 BE0000442