1.0 2016-05-25 03:16:00 UTC 2026-08-19 16:50:17 UTC Propranolol SmallMolecule Propranolol (C16H21NO2) is an organic compound with an average molecular weight of 259.34 g/mol. Propranolol belongs to the naphthalenes, a class of benzenoids within the organic compounds. It is used as a biological drug (PMC7753967) and is specifically utilized as a treatment for hypertension (PMC10384072). The compound acts as an antagonist for the Beta-1 adrenergic receptor (ADRB1), Beta-2 adrenergic receptor (ADRB2), Beta-3 adrenergic receptor (ADRB3), and the 5-hydroxytryptamine receptor 1A (HTR1A), among one other protein. Propranolol is found in or released from 23 recorded sources. These include healthcare, pharmaceuticals, and veterinary products as beta blocking agents, as well as drinking water and water supply. Other sources include food, food processing and cookware—specifically the treatment of hops, food preservation, and fermentation processes for beer—and household cleaning and consumer products such as bleaching agents, perfumes within detergents and soaps, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. It is also associated with electrical and electronic equipment, including electrodes, electric hearing aids, antennas, conductors or conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices. Recorded exposure routes for the compound include oral and intravenous administration. Health effects associated with propranolol include increases in obesity (PMC11995813) and weight gain (PMC11995813). Additionally, it is associated with hypoglycemia, hypotension, bradycardia, and bronchospasm (PMC11172932). C16H21NO2 259.3434 259.157228921 1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol propranolol 525-66-6 CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12 InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 AQHHHDLHHXJYJD-UHFFFAOYSA-N Organic compounds Benzenoids Naphthalenes Naphthalenes 1,2-aminoalcohols Alkyl aryl ethers Dialkylamines Hydrocarbon derivatives Organopnictogen compounds Secondary alcohols 1,2-aminoalcohol Alcohol Alkyl aryl ether Amine Aromatic homopolycyclic compound Ether Hydrocarbon derivative Naphthalene Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Secondary alcohol Secondary aliphatic amine Secondary amine Aromatic homopolycyclic compounds naphthalenes propanolamine secondary amine Detected and Not Quantified Propranolol Action Pathway SMP0000307 Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway SMP0126225 Propranolol B2-Adrenergic Vasoconstriction Action Pathway SMP0126650 Propranolol Drug Metabolism Action Pathway SMP0143020 logp 2.58 logp 3.03 ALOGPS logs -3.51 ALOGPS solubility 7.94e-02 g/l ALOGPS logp 2.58 ChemAxon pka_strongest_acidic 14.09 ChemAxon pka_strongest_basic 9.67 ChemAxon iupac 1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol ChemAxon average_mass 259.3434 ChemAxon mono_mass 259.157228921 ChemAxon smiles CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12 ChemAxon formula C16H21NO2 ChemAxon inchi InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 ChemAxon inchikey AQHHHDLHHXJYJD-UHFFFAOYSA-N ChemAxon polar_surface_area 41.49 ChemAxon refractivity 76.83 ChemAxon polarizability 29.98 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7267488f38> DB00571 4946 4777 BE0000172 BE0000694 BE0001012 BE0000291 BE0000797