1.0 2016-05-25 18:08:00 UTC 2026-05-14 18:09:30 UTC Aldosterone SmallMolecule Aldosterone (C21H28O5) is a compound with an average molecular weight of 360.44 g/mol. Aldosterone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound acts as an agonist or blocker for three protein targets: the Mineralocorticoid receptor (NR3C2), the Glucocorticoid receptor (NR3C1), and Solute carrier family 12 member 1 (SLC12A1). The substance is found in or released from 27 recorded sources, including medical devices from the healthcare, pharmaceuticals & veterinary products sector; drinking water from the drinking water & water supply sector; synthetic textiles, carpets and rugs from the textiles, leather & furnishings sector; and food packaging and food preservation from the food, food processing & cookware sector. Other sources include perfumes within detergents and soaps, bleaching agents, cigar cigarettes, and other smoking requisites from household cleaning & consumer products, as well as batteries, capacitors, cell phones, wires and cables, and printed circuit boards from electrical & electronic equipment. Recorded exposure routes include touch, oral, and inhalation. Aldosterone is associated with several health effects, including essential hypertension (PMC11010091), an increase in inflammation (PMC9622620), an increase in blood pressure (PMC9622620), an increase in stroke (PMC9622620), and an increase in atherosclerosis (PMC11351257). Furthermore, blood levels of the compound are elevated in cases of hypertension (PMC5552154) and heart failure (PMC3570174). PFAS C21H28O5 360.444 360.193674006 (2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde (2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde 52-39-1 C[C@]12CCC(=O)C=C1CCC1C3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)C21)C=O InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14?,15?,16-,17+,19?,20+,21-/m1/s1 PQSUYGKTWSAVDQ-SRPWZAMTSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-4-steroids Aldehydes Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Organic oxides Primary alcohols Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 18-oxosteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-4-steroid 3-oxosteroid Alcohol Aldehyde Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Aliphatic homopolycyclic compounds Detected and Not Quantified logp 1.06 logp 1.54 ALOGPS logs -3.39 ALOGPS solubility 1.48e-01 g/l ALOGPS logp 1.06 ChemAxon pka_strongest_acidic 13.82 ChemAxon pka_strongest_basic -2.9 ChemAxon iupac (2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde ChemAxon average_mass 360.444 ChemAxon mono_mass 360.193674006 ChemAxon smiles C[C@]12CCC(=O)C=C1CCC1C3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)C21)C=O ChemAxon formula C21H28O5 ChemAxon inchi InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14?,15?,16-,17+,19?,20+,21-/m1/s1 ChemAxon inchikey PQSUYGKTWSAVDQ-SRPWZAMTSA-N ChemAxon polar_surface_area 91.67 ChemAxon refractivity 96.79 ChemAxon polarizability 38.77 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226290f00> DB04630 5839 5633 BE0000668 BE0000794 BE0000502