1.0 2016-05-25 18:10:20 UTC 2026-05-14 19:00:02 UTC Serotonin SmallMolecule Serotonin (C10H12N2O) is an organic compound with an average molecular weight of 176.22 g/mol. Serotonin belongs to the tryptamines and derivatives, a subclass of indoles and derivatives within the organic compounds. Biologically, it functions as a neurotransmitter (PMC10170285, PMC10979413, PMC11885754, PMC12111777, PMC7112550, PMC8913902) and an agonist (PMC3477246). It is an inhibitor of 15 recorded protein targets, including the Sodium-dependent serotonin transporter (SLC6A4), 5-hydroxytryptamine receptor 2A (HTR2A), 5-hydroxytryptamine receptor 3A (HTR3A), and 5-hydroxytryptamine receptor 3B (HTR3B). The compound is found in or released from 34 recorded sources, including medical devices, lubricants, synthetic textiles, carpets and rugs, food packaging, food preservation, preparation of vinegar, and preparation of wort. Other sources include cell phones, capacitors, wires and cables, batteries, printed circuit boards, cigar cigarettes, non electric simulated smoking devices, other smoking requisites, perfumes within detergents and soaps, and pipe accessories. Recorded exposure routes include oral, touch, and inhalation. Serotonin is associated with several health effects, including osteoporosis (PMC10532995), pain (PMC11369511, PMC5962350), chronic pain (PMC12027284), insomnia (PMC12027284), inflammation (PMC8213022), and schizophrenia (PMC3774751, PMC7112550). It is associated with depression (PMC10662300, PMC11043594, PMC12027284, PMC12691759, PMC13198951, PMC3774751, PMC3804419, PMC4457595, PMC4836167), anxiety (PMC12562881, PMC13386386, PMC8865417), an increase in anxiety (PMC12027284, PMC12691759, PMC4457595, PMC4836167), and an increase in hypertension (PMC13409969). Decreased blood levels of the compound are noted in depression (PMC12562881, PMC13198951, PMC4836167) and decreased anxiety (PMC12562881). Additionally, serotonin has a therapeutic effect on hypertension (PMC6175881) and inflammation (PMC11548868). PFAS Phytotoxin C10H12N2O 176.2151 176.094963016 3-(2-aminoethyl)-1H-indol-5-ol serotonin 50-67-9 NCCC1=CNC2=CC=C(O)C=C12 InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 QZAYGJVTTNCVMB-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Indoles and derivatives Tryptamines and derivatives Serotonins 1-hydroxy-2-unsubstituted benzenoids 2-arylethylamines 3-alkylindoles Aralkylamines Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Hydroxyindoles Monoalkylamines Organooxygen compounds Organopnictogen compounds Substituted pyrroles 1-hydroxy-2-unsubstituted benzenoid 2-arylethylamine 3-alkylindole Amine Aralkylamine Aromatic heteropolycyclic compound Azacycle Benzenoid Heteroaromatic compound Hydrocarbon derivative Hydroxyindole Indole Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary aliphatic amine Primary amine Pyrrole Serotonin Substituted pyrrole Aromatic heteropolycyclic compounds Biogenic amines Indole alkaloids monoamine molecular messenger phenols primary amino compound tryptamines Detected and Not Quantified Tryptophan Metabolism SMP0000063 Neuron Function SMP0000224 Benzocaine Action Pathway SMP0000392 Bupivacaine Action Pathway SMP0000393 Chloroprocaine Action Pathway SMP0000394 Cocaine Action Pathway SMP0000395 Dibucaine Action Pathway SMP0000396 Levobupivacaine Action Pathway SMP0000397 Lidocaine (Local Anaesthetic) Action Pathway SMP0000398 Mepivacaine Action Pathway SMP0000399 Oxybuprocaine Action Pathway SMP0000400 Prilocaine Action Pathway SMP0000401 Procaine Action Pathway SMP0000402 Proparacaine Action Pathway SMP0000403 Ropivacaine Action Pathway SMP0000404 Codeine Action Pathway SMP0000405 Morphine Action Pathway SMP0000406 Methadone Action Pathway SMP0000408 Oxycodone Action Pathway SMP0000409 Hydromorphone Action Pathway SMP0000410 Hydrocodone Action Pathway SMP0000411 Oxymorphone Action Pathway SMP0000412 Alfentanil Action Pathway SMP0000413 Carfentanil Action Pathway SMP0000414 Fentanyl Action Pathway SMP0000415 Remifentanil Action Pathway SMP0000416 Sufentanil Action Pathway SMP0000417 Imipramine SMP0000422 Desipramine Action Pathway SMP0000423 Citalopram Action Pathway SMP0000424 Escitalopram Action Pathway SMP0000425 Fluoxetine Action Pathway SMP0000426 Nicotine Action Pathway SMP0000431 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin SMP0000309 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin SMP0000311 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin SMP0000312 Tramadol Action Action Pathway SMP0000671 Propoxyphene Action Pathway SMP0000672 Levorphanol Action Pathway SMP0000673 Anileridine Action Pathway SMP0000674 Diphenoxylate Action Pathway SMP0000675 Dezocine Action Pathway SMP0000676 Levomethadyl Acetate Action Action Pathway SMP0000677 Methadyl Acetate Action Pathway SMP0000678 3-Methylthiofentanyl Action Pathway SMP0000679 Dimethylthiambutene Action Pathway SMP0000680 Ethylmorphine Action Pathway SMP0000681 Levallorphan Action Pathway SMP0000683 Buprenorphine Action Pathway SMP0000684 Alvimopan Action Pathway SMP0000685 Pentazocine Action Pathway SMP0000686 Naltrexone Action Pathway SMP0000687 Naloxone Action Pathway SMP0000688 Dihydromorphine Action Pathway SMP0000689 Ketobemidone Action Pathway SMP0000690 Nalbuphine Action Pathway SMP0000691 Methamphetamine Dopamine Reuptake Inhibitor Action Pathway SMP0125231 Intestinal Serotonin pathway SMP0125254 Clozapine Serotonin Antagonist Action Pathway SMP0125311 Segawa Syndrome SMP0125587 Sepiapterin Reductase Deficiency SMP0125588 Nortriptyline Action Pathway SMP0126345 Trimipramine Action Pathway SMP0126348 Desipramine Action Pathway (New) SMP0126352 Clomipramine Action Pathway (New) SMP0126354 Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) SMP0126355 Imipramine Action Pathway (New) SMP0126359 Levomilnacipran SNRI - Serotonin Reuptake Inhibition Action Pathway SMP0126386 Milnacipran SNRI - Serotonin reuptake Inhibition Action Pathway SMP0126399 Vilazodone mechanism of Action Action Pathway SMP0126404 Desvenlafaxine SNRI - Serotonin reuptake Inhibition Action Pathway SMP0126423 Fluoxetine - Serotonin reuptake Inhibition Action Pathway SMP0126435 Duloxetine SNRI - Serotonin reuptake Inhibition Action Pathway SMP0126449 Aripiprazole Serotonin Agonist Action Pathway SMP0126456 Ziprasidone Serotonin Action Action Pathway SMP0126471 Thiethylperazine Serotonin Antagonist Action Pathway SMP0126477 Chlorpromazine - Serotonin Antagonist Action Pathway SMP0126487 Amoxapine SSRI Action Pathway SMP0126502 Citalopram Mechanism of Action Action Pathway New SMP0126506 Escitalopram Mechanism of Action Action Pathway New SMP0126509 Paroxetine Mechanism of Action Action Pathway New SMP0126510 Fluvoxamine Mechanism of Action Action Pathway New SMP0126511 Sertraline Mechanism of Action Action Pathway New SMP0126512 Flupentixol Serotonin Antagonist Action Pathway SMP0126516 Mesoridazine Serotonin Antagonist Action Pathway SMP0126524 Lurasidone Serotonin Antagonist Action Pathway SMP0126527 Amisulpride Serotonin Antagonist Action Pathway SMP0126531 Triflupromazine Serotonin Antagonist Action Pathway SMP0126551 Thioridazine Serotonin Antagonist Action Pathway SMP0126560 Acepromazine - Serotonin Antagonist Action Pathway SMP0126586 Chlorprothixene Serotonin Antagonist Action Pathway SMP0126587 Tiapride Serotonin Antagonist Action Pathway SMP0126590 Paliperidone Serotonin Antagonist Action Pathway SMP0126597 Risperidone Serotonin Antagonist Action Pathway SMP0126598 Amitriptyline Serotonin Antagonist Action Pathway SMP0126617 Methamphetamine Serotonin Reuptake Inhibitor Action Pathway SMP0126619 Tranylcypromine Amine Oxidase Norepinephrine Antidepressant Action Pathway SMP0126672 Lumateperone SSRI Action Action Pathway SMP0126693 Lumateperone Serotonin Antagonist Action Pathway SMP0126695 Brexpiprazole Serotonin Action Action Pathway SMP0126699 Agomelatine Serotonin Antagonist Action Pathway SMP0126726 Asenapine Serotonin antagonist Action Pathway SMP0126737 Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway SMP0126744 Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway SMP0126746 Minaprine Serotonin receptor Antidepressant Action Pathway SMP0126747 Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway SMP0126754 Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway SMP0126762 Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway SMP0126766 Ondansetron Serotonin antagonist Action Pathway SMP0126768 Dosulepin Serotonin antagonist Action Pathway SMP0126779 Tropisetron Serotonin antagonist Action Pathway SMP0126780 Palonosetron Serotonin antagonist Action Pathway SMP0126781 Dolasetron Serotonin antagonist Action Pathway SMP0126782 Iloperidone Serotonin antagonist Action Pathway SMP0126784 Flibanserin Serotonin Action Action Pathway SMP0126786 Granisetron Serotonin antagonist Action Pathway SMP0126787 Vortioxetine Serotonin Action Action Pathway SMP0126788 Quetiapine Serotonin Antagonist Action Pathway SMP0126799 Pipotiazine Serotonin antagonist Action Pathway SMP0126800 Olanzapine Serotonin Antagonist Action Pathway SMP0126804 Mirtazapine Serotonin Antagonist Action Pathway SMP0126817 Minaprine Serotonin Antagonist Action Pathway SMP0126818 Lorpiprazole Serotonin antagonist Action Pathway SMP0126822 Cyproheptadine Serotonin Antagonist Action Pathway SMP0126842 Cyclobenzaprine Serotonin antagonist Action Pathway SMP0126845 Methysergide Mechanism of Action Action Pathway SMP0126851 Gq Serotonergic Smooth Muscle Contraction SMP0126954 Gi Serotonergic Smooth Muscle Relaxation SMP0126986 Gi Serotonergic Vasoconstriction SMP0126992 Gs Serotonergic Smooth Muscle Contraction SMP0127045 Amine Oxidase Serotonin SMP0130456 logp 0.48 logp 0.56 ALOGPS logs -1.85 ALOGPS solubility 2.50e+00 g/l ALOGPS logp 0.48 ChemAxon pka_strongest_acidic 9.31 ChemAxon pka_strongest_basic 10 ChemAxon iupac 3-(2-aminoethyl)-1H-indol-5-ol ChemAxon average_mass 176.2151 ChemAxon mono_mass 176.094963016 ChemAxon smiles NCCC1=CNC2=CC=C(O)C=C12 ChemAxon formula C10H12N2O ChemAxon inchi InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 ChemAxon inchikey QZAYGJVTTNCVMB-UHFFFAOYSA-N ChemAxon polar_surface_area 62.04 ChemAxon refractivity 52.35 ChemAxon polarizability 19.31 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 2 ChemAxon donor_count 3 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7227886a58> DB08839 5202 5013 BE0000749 BE0000451 BE0000311 BE0004862 BE0000118 BE0000797 BE0000533 BE0000084 BE0004688 BE0000659 BE0000945 BE0000291 BE0000393 BE0000354 BE0000650