1.0 2016-05-25 18:12:38 UTC 2026-05-14 16:37:17 UTC Phenylephrine SmallMolecule Phenylephrine is an organic compound with the formula C9H13NO2 and an average molecular weight of 167.21 g/mol. Phenylephrine belongs to the 1-hydroxy-4-unsubstituted benzenoids, a subclass of phenols within the organic compounds. It is recorded as an agonist for the D(2) dopamine receptor (DRD2) as well as the Alpha-1A, Alpha-1B, and Alpha-1D adrenergic receptors (ADRA1A, ADRA1B, and ADRA1D). The compound is found in or released from 24 recorded sources across several categories. Within healthcare, pharmaceuticals, and veterinary products, it is used in nasal preparations, decongestants and antiallergics, mydriatics and cycloplegics, vasoprotectives, and cardiac stimulants excluding cardiac glycosides. In the context of food and food processing, it is associated with food preservation, the preparation of vinegar, and fermentation processes for beer. It is also found in drinking water, ceilings, and various household cleaning and consumer products, including perfumes within detergents and soaps, tobacco product cases, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. Additionally, it is found in electrical and electronic equipment, such as electrodes, electrically stimulated smoking devices, electric hearing aids, communication cables or conductors, and conductors or conductive bodies characterised by the conductive materials. Recorded exposure routes for phenylephrine include oral, nasal, ophthalmic, intraocular, auricular, intravenous, intramuscular, subcutaneous, rectal, respiratory, topical, and irrigation. C9H13NO2 167.205 167.094628665 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol phenylephrine 59-42-7 CNC[C@H](O)C1=CC(O)=CC=C1 InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1 SONNWYBIRXJNDC-VIFPVBQESA-N Organic compounds Benzenoids Phenols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids 1,2-aminoalcohols 1-hydroxy-2-unsubstituted benzenoids Aralkylamines Aromatic alcohols Benzene and substituted derivatives Dialkylamines Hydrocarbon derivatives Organopnictogen compounds Secondary alcohols 1,2-aminoalcohol 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid Alcohol Amine Aralkylamine Aromatic alcohol Aromatic homomonocyclic compound Hydrocarbon derivative Monocyclic benzene moiety Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Secondary alcohol Secondary aliphatic amine Secondary amine Aromatic homomonocyclic compounds phenylethanolamines secondary amino compound Detected and Not Quantified Phenylephrine Action Pathway SMP0125242 Phenylephrine Drug Metabolism Action Pathway SMP0142845 logp -0.07 logp -0.69 ALOGPS logs -0.88 ALOGPS solubility 2.20e+01 g/l ALOGPS logp -0.07 ChemAxon pka_strongest_acidic 9.07 ChemAxon pka_strongest_basic 9.69 ChemAxon iupac 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol ChemAxon average_mass 167.205 ChemAxon mono_mass 167.094628665 ChemAxon smiles CNC[C@H](O)C1=CC(O)=CC=C1 ChemAxon formula C9H13NO2 ChemAxon inchi InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1 ChemAxon inchikey SONNWYBIRXJNDC-VIFPVBQESA-N ChemAxon polar_surface_area 52.49 ChemAxon refractivity 47.25 ChemAxon polarizability 18.2 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 3 ChemAxon donor_count 3 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7224703030> DB00388 6041 5818 BE0000501 BE0000575 BE0000715 BE0000756