1.0 2016-05-25 18:14:34 UTC 2026-09-01 06:32:31 UTC Angiotensin II SmallMolecule Angiotensin II (C50H71N13O12) belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 1,046 g/mol, Angiotensin II is a heavy molecule. It acts as an agonist or inhibitor of two protein targets: the Type-1 angiotensin II receptor (AGTR1) and the Type-2 angiotensin II receptor (AGTR2). The compound is found in or released from eight recorded sources, including electrical and electronic equipment such as antennas, television systems, gas filled discharge tubes with gaseous cathodes, and discharge tubes with liquid pool cathodes. Other sources include the preparation of wine or sparkling wine, the preparation of vinegar, other smoking requisites, and cardiac stimulants excluding cardiac glycosides. The recorded exposure route is intravenous. Angiotensin II is associated with several health effects. It is linked to cardiomyopathy (PMC12712907), heart failure (PMC6210295), and hyperglycemia (PMC9368651). It is associated with inflammation (PMC12028762, PMC6273216) and an increase in atherosclerosis (PMC10889477, PMC11351257) and proteinuria (PMC3136362). Regarding blood pressure, the compound is associated with hypertension (PMC4302234, PMC6151556) and an increase in blood pressure (PMC11277057, PMC12146500, PMC12722972, PMC6567131), though it is also associated with a decrease in high blood pressure (PMC12028762). C50H71N13O12 1046.1786 1045.534514801 (3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid (3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid 11128-99-7 CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 CZGUSIXMZVURDU-JZXHSEFVSA-N Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Oligopeptides 1-hydroxy-2-unsubstituted benzenoids Alpha amino acid amides Amino acids Amphetamines and derivatives Aspartic acid and derivatives Azacyclic compounds Carbonyl compounds Carboximidamides Carboxylic acids Dicarboxylic acids and derivatives Guanidines Heteroaromatic compounds Histidine and derivatives Hydrocarbon derivatives Imidazolyl carboxylic acids and derivatives Isoleucine and derivatives Monoalkylamines N-acyl amines N-acyl-L-alpha-amino acids N-acylpyrrolidines Organic oxides Organopnictogen compounds Phenylalanine and derivatives Phenylpropanoic acids Proline and derivatives Propargyl-type 1,3-dipolar organic compounds Pyrrolidinecarboxamides Secondary carboxylic acid amides Tertiary carboxylic acid amides Tyrosine and derivatives Valine and derivatives 1-hydroxy-2-unsubstituted benzenoid 3-phenylpropanoic-acid Alpha-amino acid amide Alpha-amino acid or derivatives Alpha-oligopeptide Amine Amino acid Amino acid or derivatives Amphetamine or derivatives Aromatic heteromonocyclic compound Aspartic acid or derivatives Azacycle Azole Benzenoid Carbonyl group Carboxamide group Carboximidamide Carboxylic acid Dicarboxylic acid or derivatives Fatty acyl Fatty amide Guanidine Heteroaromatic compound Histidine or derivatives Hydrocarbon derivative Imidazole Imidazolyl carboxylic acid derivative Isoleucine or derivatives Monocyclic benzene moiety N-acyl-alpha amino acid or derivatives N-acyl-alpha-amino acid N-acyl-amine N-acyl-l-alpha-amino acid N-acylpyrrolidine N-substituted-alpha-amino acid Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenol Phenylalanine or derivatives Primary aliphatic amine Primary amine Proline or derivatives Propargyl-type 1,3-dipolar organic compound Pyrrolidine Pyrrolidine carboxylic acid or derivatives Pyrrolidine-2-carboxamide Secondary carboxylic acid amide Tertiary carboxylic acid amide Tyrosine or derivatives Valine or derivatives Aromatic heteromonocyclic compounds Angiotensin [KO:K09821] angiotensin II Detected and Not Quantified Benazepril Action Pathway SMP0000145 Captopril Action Pathway SMP0000146 Cilazapril Action Pathway SMP0000147 Enalapril Action Pathway SMP0000148 Fosinopril Action Pathway SMP0000149 Lisinopril Action Pathway SMP0000150 Moexipril Action Pathway SMP0000151 Perindopril Action Pathway SMP0000152 Quinapril Action Pathway SMP0000153 Ramipril Action Pathway SMP0000154 Rescinnamine Action Pathway SMP0000155 Spirapril Action Pathway SMP0000156 Trandolapril Action Pathway SMP0000157 Candesartan Action Pathway SMP0000158 Eprosartan Action Pathway SMP0000159 Forasartan Action Pathway SMP0000160 Irbesartan Action Pathway SMP0000161 Losartan Action Pathway SMP0000162 Olmesartan Action Pathway SMP0000163 Telmisartan Action Pathway SMP0000164 Valsartan Action Pathway SMP0000165 Angiotensin Metabolism SMP0000587 Temocapril Action Pathway SMP0000733 Kidney Function - Ascending Limb of The Loop of Henle SMP0121010 Kidney Function - Collecting Duct SMP0121011 Kidney Function - Distal Convoluted Tubule SMP0121012 Aldosterone from Steroidogenesis SMP0121126 Benazepril ACE inhibitor Action Pathway SMP0122803 Cilazapril ACE inhibitor Action Pathway SMP0122986 Enalapril ACE Inhibitor Action Pathway SMP0123086 Fosinopril ACE Inhibitor Action Pathway SMP0123090 Lisinopril ACE Inhibitor SMP0123091 Moexipril ACE Inhibitor Action Pathway SMP0123092 Perindopril ACE Inhibitor Action Pathway SMP0123093 Quinapril ACE Inhibitor Action Pathway SMP0123094 Ramipril ACE Inhibitor Action Pathway SMP0123095 Trandolapril ACE Inhibitor Action Pathway SMP0123104 Losartan Angiotensin blocker Action Pathway SMP0124963 Candesartan Action Pathway (New) SMP0124964 Forasartan Angiotensin Blocker Action Pathway SMP0124966 Irbesartan Angiotensin blocker Action Pathway SMP0124967 Olmesartan ARB Action Pathway SMP0124968 Telmisartan Action Pathway (New) SMP0124969 Valsartan Action Pathway (New) SMP0124970 Fimasartan Action Pathway SMP0125993 Azilsartan medoxomil Action Pathway SMP0126012 Tasosartan Action Pathway SMP0126013 Saprisartan Action Pathway SMP0126015 Candesartan cilexetil Action Pathway SMP0126016 Zofenopril Action Pathway SMP0126074 ACE SMP0127068 logp -1.7 logp -0.87 ALOGPS logs -4.83 ALOGPS solubility 1.56e-02 g/l ALOGPS logp -5.3 ChemAxon pka_strongest_acidic 3.15 ChemAxon pka_strongest_basic 10.83 ChemAxon iupac (3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid ChemAxon average_mass 1046.1786 ChemAxon mono_mass 1045.534514801 ChemAxon smiles CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O ChemAxon formula C50H71N13O12 ChemAxon inchi InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 ChemAxon inchikey CZGUSIXMZVURDU-JZXHSEFVSA-N ChemAxon polar_surface_area 408.84 ChemAxon refractivity 269.81 ChemAxon polarizability 107.02 ChemAxon rotatable_bond_count 29 ChemAxon acceptor_count 17 ChemAxon donor_count 13 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226cd8fd0> DB11842 172198 BE0000062 BE0003426