1.0 2016-05-25 18:19:47 UTC 2026-08-20 04:04:25 UTC Alfuzosin SmallMolecule Alfuzosin is an organic compound with the formula C19H27N5O4 and an average molecular weight of 389.45 g/mol. Alfuzosin belongs to the benzodiazines, a subclass of diazanaphthalenes within the organic compounds. This substance functions as an antagonist of three protein targets: the Alpha-1A adrenergic receptor (ADRA1A), the Alpha-1B adrenergic receptor (ADRA1B), and the Alpha-1D adrenergic receptor (ADRA1D). The compound is identified in six recorded sources across various categories. In the realm of healthcare, pharmaceuticals, and veterinary products, it is utilized as a drug for the treatment of benign prostatic hypertrophy. It is also found in household cleaning and consumer products, specifically within tobacco smoke filters, cigar cigarettes, and other smoking requisites. Additionally, it has been detected in indoor air as part of air, dust, and atmospheric transport, as well as in electrically stimulated smoking devices categorized under electrical and electronic equipment. Exposure to alfuzosin occurs through oral and inhalation routes. Human Neurotoxin C19H27N5O4 389.4488 389.206304377 N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}oxolane-2-carboxamide alfuzosin 81403-80-7 COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N(C)CCCNC(=O)C1CCCO1 InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23) WNMJYKCGWZFFKR-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Quinazolinamines Alkyl aryl ethers Aminopyrimidines and derivatives Anisoles Azacyclic compounds Carboximidic acids Dialkyl ethers Dialkylarylamines Heteroaromatic compounds Hydrocarbon derivatives Imidolactams Organopnictogen compounds Oxacyclic compounds Propargyl-type 1,3-dipolar organic compounds Tetrahydrofurans Alkyl aryl ether Aminopyrimidine Anisole Aromatic heteropolycyclic compound Azacycle Benzenoid Carboximidic acid Carboximidic acid derivative Dialkyl ether Dialkylarylamine Ether Heteroaromatic compound Hydrocarbon derivative Imidolactam Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Propargyl-type 1,3-dipolar organic compound Pyrimidine Quinazolinamine Tetrahydrofuran Aromatic heteropolycyclic compounds monocarboxylic acid amide quinazolines tetrahydrofuranol Detected and Not Quantified Alfuzosin Drug Metabolism Action Pathway SMP0142804 logp 1.19 logp 2.02 ALOGPS logs -3.14 ALOGPS solubility 2.82e-01 g/l ALOGPS logp 1.19 ChemAxon pka_strongest_acidic 14.64 ChemAxon pka_strongest_basic 7.3 ChemAxon iupac N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}oxolane-2-carboxamide ChemAxon average_mass 389.4488 ChemAxon mono_mass 389.206304377 ChemAxon smiles COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N(C)CCCNC(=O)C1CCCO1 ChemAxon formula C19H27N5O4 ChemAxon inchi InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23) ChemAxon inchikey WNMJYKCGWZFFKR-UHFFFAOYSA-N ChemAxon polar_surface_area 111.83 ChemAxon refractivity 107.11 ChemAxon polarizability 42.71 ChemAxon rotatable_bond_count 8 ChemAxon acceptor_count 8 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bae668e88> DB00346 2092 2008 BE0000501 BE0000575 BE0000715