1.0 2016-05-25 18:19:59 UTC 2026-08-21 22:49:11 UTC Thiethylperazine SmallMolecule Thiethylperazine is an organic compound with the chemical formula C22H29N3S2 and an average molecular weight of 399.62 g/mol. Thiethylperazine belongs to the phenothiazines, a subclass of benzothiazines within the organic compounds. It is categorized under the superclass of organoheterocyclic compounds. Regarding its biological activity, thiethylperazine acts as an antagonist of the D(2) dopamine receptor (DRD2). The compound is found in or released from six recorded sources, including healthcare, pharmaceuticals, and veterinary products where it is used as an antihistamine. It is also associated with household cleaning and consumer products, specifically perfumes within detergents and soaps, non electric simulated smoking devices, and tobacco smoke filters. Additionally, it is found in electrical and electronic equipment, specifically conductors or conductive bodies characterised by the conductive materials and antennas. Recorded exposure routes for this compound include oral and intramuscular administration. C22H29N3S2 399.616 399.180289323 2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine thiethylperazine 1420-55-9 CCSC1=CC2=C(SC3=CC=CC=C3N2CCCN2CCN(C)CC2)C=C1 InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 XCTYLCDETUVOIP-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Benzothiazines Phenothiazines Phenothiazines 1,4-thiazines Alkylarylthioethers Alkyldiarylamines Azacyclic compounds Diarylthioethers Hydrocarbon derivatives N-methylpiperazines Organopnictogen compounds Sulfenyl compounds Thiophenol ethers Trialkylamines 1,4-diazinane Alkylarylthioether Alkyldiarylamine Amine Aromatic heteropolycyclic compound Aryl thioether Azacycle Benzenoid Diarylthioether Hydrocarbon derivative N-alkylpiperazine N-methylpiperazine Organic nitrogen compound Organonitrogen compound Organopnictogen compound Organosulfur compound Para-thiazine Phenothiazine Piperazine Sulfenyl compound Tertiary aliphatic amine Tertiary aliphatic/aromatic amine Tertiary amine Thioether Thiophenol ether Aromatic heteropolycyclic compounds N-methylpiperazine phenothiazines Detected and Not Quantified Thiethylperazine Dopamine Antagonist Action Pathway SMP0126476 Thiethylperazine Serotonin Antagonist Action Pathway SMP0126477 Thiethylperazine Drug Metabolism Action Pathway SMP0142830 logp 4.66 logp 5.12 ALOGPS logs -4.91 ALOGPS solubility 4.87e-03 g/l ALOGPS logp 4.66 ChemAxon pka_strongest_basic 8.4 ChemAxon iupac 2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine ChemAxon average_mass 399.616 ChemAxon mono_mass 399.180289323 ChemAxon smiles CCSC1=CC2=C(SC3=CC=CC=C3N2CCCN2CCN(C)CC2)C=C1 ChemAxon formula C22H29N3S2 ChemAxon inchi InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 ChemAxon inchikey XCTYLCDETUVOIP-UHFFFAOYSA-N ChemAxon polar_surface_area 9.72 ChemAxon refractivity 122.56 ChemAxon polarizability 46.53 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 3 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721fab89a0> DB00372 5440 5245 BE0000756