1.0 2016-05-25 18:21:28 UTC 2026-08-22 00:35:23 UTC Doxazosin SmallMolecule Doxazosin is an organic compound with the formula C23H25N5O5 and an average molecular weight of 451.48 g/mol. Doxazosin belongs to the piperazines, a subclass of diazinanes within the organic compounds. It is recorded as being found in or released from 36 sources, including healthcare, pharmaceuticals, and veterinary products such as antihypertensives and drugs used in benign prostatic hypertrophy. Other sources include food preservation and fermentation processes for beer, building and construction materials like floors, ceilings, tents or canopies, and household cleaning and consumer products such as tobacco smoke filters, perfumes within detergents and soaps, non electric simulated smoking devices, cigar cigarettes, and other smoking requisites. Additionally, it is associated with electrical and electronic equipment, including antennas, amplifiers, auxiliary devices, cores yokes or armatures, and conductors or conductive bodies characterised by the conductive materials. The recorded exposure route for this compound is oral. Doxazosin acts on six recorded protein targets, serving as an antagonist/inhibitor of the Alpha-1A adrenergic receptor (ADRA1A), the Alpha-1D adrenergic receptor (ADRA1D), the voltage-gated inwardly rectifying potassium channel KCNH2, the voltage-gated inwardly rectifying potassium channel KCNH6, and two other proteins. In terms of health effects, it is used as a treatment for pheochromocytoma (PMC10074227). C23H25N5O5 451.4751 451.185568935 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine doxazosin 74191-85-8 COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1 InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26) RUZYUOTYCVRMRZ-UHFFFAOYSA-N Detected and Not Quantified Doxazosin Drug Metabolism Action Pathway SMP0143038 Doxazosin Predicted Metabolism Pathway SMP0174701 logp 2.14 logp 2.53 ALOGPS logs -2.76 ALOGPS solubility 7.90e-01 g/l ALOGPS logp 2.14 ChemAxon pka_strongest_acidic 12.67 ChemAxon pka_strongest_basic 7.24 ChemAxon iupac 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine ChemAxon average_mass 451.4751 ChemAxon mono_mass 451.185568935 ChemAxon smiles COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1 ChemAxon formula C23H25N5O5 ChemAxon inchi InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26) ChemAxon inchikey RUZYUOTYCVRMRZ-UHFFFAOYSA-N ChemAxon polar_surface_area 112.27 ChemAxon refractivity 121.64 ChemAxon polarizability 46.63 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 9 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bafd5f1f0> DB00590 3157 3045 BE0000501 BE0000715 BE0000090 BE0000462 BE0000699 BE0000575