1.0 2016-05-25 18:22:17 UTC 2026-08-20 04:44:19 UTC Trovafloxacin SmallMolecule Trovafloxacin is an organic compound with the formula C20H15F3N4O3 and an average molecular weight of 416.35 g/mol. Trovafloxacin belongs to the naphthyridines, a subclass of diazanaphthalenes within the organic compounds. It is further classified as an organoheterocyclic compound. The compound is found in or released from three recorded sources: antennas within electrical and electronic equipment, and quinolone antibacterials and antibiotics within healthcare, pharmaceuticals, and veterinary products. Recorded exposure routes for this substance include intravenous, oral, and inhalation. In terms of biological activity, trovafloxacin acts as an inhibitor or modulator of four recorded protein targets. These include DNA gyrase subunit A (gyrA), DNA gyrase subunit B (gyrB), DNA topoisomerase 4 subunit A (parC), and DNA topoisomerase 2-alpha (TOP2A). Human Neurotoxin C20H15F3N4O3 416.3533 416.109624981 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid trovafloxacin 147059-72-1 [H][C@@]12CN(C[C@]1([H])C2N)C1=C(F)C=C2C(=O)C(=CN(C3=C(F)C=C(F)C=C3)C2=N1)C(O)=O InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16? WVPSKSLAZQPAKQ-SOSAQKQKSA-N Organic compounds Organoheterocyclic compounds Diazanaphthalenes Naphthyridines Naphthyridine carboxylic acids and derivatives Amino acids Aminopiperidines Aminopyridines and derivatives Aryl fluorides Azacyclic compounds Carboxylic acids Dialkylarylamines Fluorobenzenes Fluoroquinolones Heteroaromatic compounds Hydrocarbon derivatives Imidolactams Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organofluorides Organooxygen compounds Organopnictogen compounds Pyridinecarboxylic acids Pyrrolidines Vinylogous amides 4-aminopiperidine Amine Amino acid Amino acid or derivatives Aminopyridine Aromatic heteropolycyclic compound Aryl fluoride Aryl halide Azacycle Benzenoid Carboxylic acid Carboxylic acid derivative Dialkylarylamine Fluorobenzene Fluoroquinolone Halobenzene Heteroaromatic compound Hydrocarbon derivative Imidolactam Monocarboxylic acid or derivatives Monocyclic benzene moiety Naphthyridine carboxylic acid Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Piperidine Primary aliphatic amine Primary amine Pyridine Pyridine carboxylic acid Pyridine carboxylic acid or derivatives Pyrrolidine Vinylogous amide Aromatic heteropolycyclic compounds Detected and Not Quantified Trovafloxacin Drug Metabolism Action Pathway SMP0143129 logp 0.14 logp 0.86 ALOGPS logs -3.77 ALOGPS solubility 7.04e-02 g/l ALOGPS logp 0.14 ChemAxon pka_strongest_acidic 5.41 ChemAxon pka_strongest_basic 9.44 ChemAxon iupac 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid ChemAxon average_mass 416.3533 ChemAxon mono_mass 416.109624981 ChemAxon smiles [H][C@@]12CN(C[C@]1([H])C2N)C1=C(F)C=C2C(=O)C(=CN(C3=C(F)C=C(F)C=C3)C2=N1)C(O)=O ChemAxon formula C20H15F3N4O3 ChemAxon inchi InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16? ChemAxon inchikey WVPSKSLAZQPAKQ-SOSAQKQKSA-N ChemAxon polar_surface_area 99.76 ChemAxon refractivity 101.04 ChemAxon polarizability 38.34 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 7 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bbf8730c8> DB00685 11464175 56670 BE0000366 BE0000429 BE0000742 BE0008385 BE0002388