1.0 2016-05-25 18:22:38 UTC 2026-08-21 18:35:12 UTC Naftifine SmallMolecule Naftifine is an organic compound with the formula C21H21N and an average molecular weight of 287.41 g/mol. Naftifine belongs to the naphthalenes, a class of benzenoids within the organic compounds. In terms of biological activity, it acts as an inhibitor of the protein target squalene monooxygenase (SQLE). This compound is found in or released from four recorded sources: healthcare, pharmaceuticals and veterinary products, specifically antibiotics and antifungals for dermatological use; electrical and electronic equipment, specifically antennas; and household cleaning and consumer products, specifically other smoking requisites. Recorded exposure routes for Naftifine include topical, oral, and inhalation. C21H21N 287.406 287.16739968 methyl[(naphthalen-1-yl)methyl][(2E)-3-phenylprop-2-en-1-yl]amine naftifine 65472-88-0 [H]\C(CN(C)CC1=CC=CC2=CC=CC=C12)=C(\[H])C1=CC=CC=C1 InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+ OZGNYLLQHRPOBR-DHZHZOJOSA-N Organic compounds Benzenoids Naphthalenes Naphthalenes Aralkylamines Hydrocarbon derivatives Organopnictogen compounds Styrenes Trialkylamines Amine Aralkylamine Aromatic homopolycyclic compound Hydrocarbon derivative Monocyclic benzene moiety Naphthalene Organic nitrogen compound Organonitrogen compound Organopnictogen compound Styrene Tertiary aliphatic amine Tertiary amine Aromatic homopolycyclic compounds allylamine antifungal drug naphthalenes tertiary amine Detected and Not Quantified Naftifine Action Pathway SMP0125827 Naftifine Drug Metabolism Action Pathway SMP0143178 logp 5.24 logp 4.96 ALOGPS logs -6.10 ALOGPS solubility 2.29e-04 g/l ALOGPS logp 5.24 ChemAxon pka_strongest_basic 8.79 ChemAxon iupac methyl[(naphthalen-1-yl)methyl][(2E)-3-phenylprop-2-en-1-yl]amine ChemAxon average_mass 287.406 ChemAxon mono_mass 287.16739968 ChemAxon smiles [H]\C(CN(C)CC1=CC=CC2=CC=CC=C12)=C(\[H])C1=CC=CC=C1 ChemAxon formula C21H21N ChemAxon inchi InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+ ChemAxon inchikey OZGNYLLQHRPOBR-DHZHZOJOSA-N ChemAxon polar_surface_area 3.24 ChemAxon refractivity 95.98 ChemAxon polarizability 34.38 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726c485798> DB00735 73342 43344 BE0000577