1.0 2016-05-25 18:22:46 UTC 2026-08-20 02:53:13 UTC Dolasetron SmallMolecule Dolasetron is an organic compound with the chemical formula C19H20N2O3 and an average molecular weight of 324.37 g/mol. Dolasetron belongs to the indolecarboxylic acids and derivatives, a subclass of indoles and derivatives within the organic compounds. It is categorized under the superclass of organoheterocyclic compounds. In terms of biological activity, dolasetron acts as an antagonist of the 5-hydroxytryptamine receptor 3A (HTR3A). It is utilized in healthcare, pharmaceuticals, and veterinary products as an antiemetic and antinauseant. Recorded routes of exposure for the compound include oral and intravenous administration. The compound has been identified in seven recorded sources. These include household cleaning and consumer products such as tobacco smoke filters, cigar cigarettes, and other smoking requisites. It is also found in electrical and electronic equipment, specifically within antennas, line transmission systems, and electrically stimulated smoking devices. C19H20N2O3 324.3737 324.147392516 (3R)-10-oxo-8-azatricyclo[5.3.1.0³,⁸]undecan-5-yl 1H-indole-3-carboxylate dolasetron 115956-12-2 [H][C@]12CC(CC3CC(C1)C(=O)CN23)OC(=O)C1=CNC2=CC=CC=C12 InChI=1S/C19H20N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,20H,5-8,10H2/t11?,12-,13?,14?/m1/s1 UKTAZPQNNNJVKR-DBBXXEFVSA-N Organic compounds Organoheterocyclic compounds Indoles and derivatives Indolecarboxylic acids and derivatives Indolecarboxylic acids and derivatives Amino acids and derivatives Azacyclic compounds Benzenoids Carboxylic acid esters Heteroaromatic compounds Hydrocarbon derivatives Indoles Ketones Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Piperidinones Pyrrole carboxylic acids and derivatives Quinolizidines Quinuclidones Substituted pyrroles Trialkylamines Vinylogous amides Amine Amino acid or derivatives Aromatic heteropolycyclic compound Azacycle Benzenoid Carbonyl group Carboxylic acid derivative Carboxylic acid ester Heteroaromatic compound Hydrocarbon derivative Indole Indolecarboxylic acid derivative Ketone Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Piperidine Piperidinone Pyrrole Pyrrole-3-carboxylic acid or derivatives Quinolizidine Quinuclidine Quinuclidone Substituted pyrrole Tertiary aliphatic amine Tertiary amine Vinylogous amide Aromatic heteropolycyclic compounds Detected and Not Quantified Dolasetron Serotonin antagonist Action Pathway SMP0126782 Dolasetron Drug Metabolism Action Pathway SMP0143200 logp 2.33 logp 2.41 ALOGPS logs -3.09 ALOGPS solubility 2.61e-01 g/l ALOGPS logp 2.33 ChemAxon pka_strongest_acidic 12.18 ChemAxon pka_strongest_basic 6.88 ChemAxon iupac (3R)-10-oxo-8-azatricyclo[5.3.1.0³,⁸]undecan-5-yl 1H-indole-3-carboxylate ChemAxon average_mass 324.3737 ChemAxon mono_mass 324.147392516 ChemAxon smiles [H][C@]12CC(CC3CC(C1)C(=O)CN23)OC(=O)C1=CNC2=CC=CC=C12 ChemAxon formula C19H20N2O3 ChemAxon inchi InChI=1S/C19H20N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,20H,5-8,10H2/t11?,12-,13?,14?/m1/s1 ChemAxon inchikey UKTAZPQNNNJVKR-DBBXXEFVSA-N ChemAxon polar_surface_area 62.4 ChemAxon refractivity 89.34 ChemAxon polarizability 33.69 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7225c1b238> DB00757 3148 3036 BE0000311