1.0 2016-05-25 18:23:27 UTC 2026-05-14 16:51:55 UTC Granisetron SmallMolecule Granisetron is an organic compound with the chemical formula C18H24N4O and an average molecular weight of 312.41 g/mol. Granisetron belongs to the indazoles, a subclass of benzopyrazoles within the organic compounds. It is classified as an organoheterocyclic compound. The compound acts as an antagonist of two protein targets: 5-hydroxytryptamine receptor 3A (HTR3A) and 5-hydroxytryptamine receptor 3B (HTR3B). Granisetron is found in or released from two recorded sources, which include indoor air (Air, dust & atmospheric transport) and antiemetics and antinauseants (Healthcare, pharmaceuticals & veterinary products). Recorded exposure routes for this substance include oral, intravenous, subcutaneous, topical, transdermal, and inhalation. C18H24N4O 312.4094 312.19501141 1-methyl-N-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}-1H-indazole-3-carboxamide GRAN 109889-09-0 CN1N=C(C(=O)NC2CC3CCCC(C2)N3C)C2=CC=CC=C12 InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23) MFWNKCLOYSRHCJ-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Benzopyrazoles Indazoles Indazole-3-carboxamides 2-heteroaryl carboxamides Amino acids and derivatives Azacyclic compounds Benzenoids Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organooxygen compounds Organopnictogen compounds Piperidines Pyrazole-5-carboxamides Secondary carboxylic acid amides Trialkylamines 2-heteroaryl carboxamide Amine Amino acid or derivatives Aromatic heteropolycyclic compound Azacycle Azole Benzenoid Carboxamide group Carboxylic acid derivative Heteroaromatic compound Hydrocarbon derivative Indazole-3-carboxamide Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Piperidine Pyrazole Pyrazole-5-carboxamide Secondary carboxylic acid amide Tertiary aliphatic amine Tertiary amine Aromatic heteropolycyclic compounds Detected and Not Quantified Granisetron Serotonin antagonist Action Pathway SMP0126787 Granisetron Drug Metabolism Action Pathway SMP0143323 Granisetron Predicted Metabolism Pathway SMP0174841 logp 1.88 logp 2.64 ALOGPS logs -2.86 ALOGPS solubility 4.34e-01 g/l ALOGPS logp 1.88 ChemAxon pka_strongest_acidic 14.75 ChemAxon pka_strongest_basic 9 ChemAxon iupac 1-methyl-N-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}-1H-indazole-3-carboxamide ChemAxon average_mass 312.4094 ChemAxon mono_mass 312.19501141 ChemAxon smiles CN1N=C(C(=O)NC2CC3CCCC(C2)N3C)C2=CC=CC=C12 ChemAxon formula C18H24N4O ChemAxon inchi InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23) ChemAxon inchikey MFWNKCLOYSRHCJ-UHFFFAOYSA-N ChemAxon polar_surface_area 50.16 ChemAxon refractivity 101.83 ChemAxon polarizability 35.39 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bae13e930> DB00889 3510 3390 BE0000311 BE0004862