1.0 2016-05-25 18:23:58 UTC 2026-08-25 06:56:17 UTC Apraclonidine SmallMolecule Apraclonidine is an organic compound with the chemical formula C9H10Cl2N4 and an average molecular weight of 245.11 g/mol. Apraclonidine belongs to the halobenzenes, a subclass of benzene and substituted derivatives within the organic compounds. It is categorized under the superclass of benzenoids. The compound acts as an agonist for three recorded protein targets: the Alpha-2A adrenergic receptor (ADRA2A), the Alpha-1A adrenergic receptor (ADRA1A), and the Alpha-2B adrenergic receptor (ADRA2B). Regarding its recorded exposure routes, it is administered ophthalmically. Apraclonidine is found in or released from seven recorded sources. Within the category of healthcare, pharmaceuticals, and veterinary products, it is used in miotics and antiglaucoma preparations. It is also associated with electrical and electronic equipment, specifically electrically stimulated smoking devices. Additionally, it is present in household cleaning and consumer products, including perfumes within detergents and soaps, tobacco smoke filters, cigar cigarettes, non-electric simulated smoking devices, and other smoking requisites. Human Neurotoxin C9H10Cl2N4 245.109 244.028251754 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine apraclonidine 66711-21-5 NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1 InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15) IEJXVRYNEISIKR-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Halobenzenes Dichlorobenzenes Aniline and substituted anilines Aryl chlorides Azacyclic compounds Carboximidamides Guanidines Hydrocarbon derivatives Imidazolines Organochlorides Organopnictogen compounds Primary amines Propargyl-type 1,3-dipolar organic compounds 1,3-dichlorobenzene 2-imidazoline Amine Aniline or substituted anilines Aromatic heteromonocyclic compound Aryl chloride Aryl halide Azacycle Carboximidamide Guanidine Hydrocarbon derivative Organic 1,3-dipolar compound Organic nitrogen compound Organochloride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Primary amine Propargyl-type 1,3-dipolar organic compound Aromatic heteromonocyclic compounds dichlorobenzene guanidines imidazolines Detected and Not Quantified Apraclonidine Drug Metabolism Action Pathway SMP0143394 logp 1.66 logp 2.14 ALOGPS logs -2.78 ALOGPS solubility 4.09e-01 g/l ALOGPS logp 1.66 ChemAxon pka_strongest_basic 8.48 ChemAxon iupac 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine ChemAxon average_mass 245.109 ChemAxon mono_mass 244.028251754 ChemAxon smiles NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1 ChemAxon formula C9H10Cl2N4 ChemAxon inchi InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15) ChemAxon inchikey IEJXVRYNEISIKR-UHFFFAOYSA-N ChemAxon polar_surface_area 62.44 ChemAxon refractivity 63.79 ChemAxon polarizability 23.27 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f722575fc80> DB00964 2216 2130 BE0000289 BE0000501 BE0000572