1.0 2016-05-25 18:24:23 UTC 2026-08-25 22:43:32 UTC Guanfacine SmallMolecule Guanfacine is an organic compound with the chemical formula C9H9Cl2N3O and an average molecular weight of 246.09 g/mol. Guanfacine belongs to the halobenzenes, a subclass of benzene and substituted derivatives within the organic compounds. The compound is recorded as being found in or released from 11 different sources. Within healthcare, pharmaceuticals, and veterinary products, it is used as an antihypertensive. In the category of food, food processing, and cookware, it is used for food preservation. It is also associated with household cleaning and consumer products, including perfumes within detergents and soaps, tobacco smoke filters, and non-electric simulated smoking devices. Furthermore, it is linked to electrical and electronic equipment, specifically antennas, conductors or conductive bodies characterised by the conductive materials, electrically stimulated smoking devices, electrodes, radio transmission systems, and one additional source. The recorded route of exposure for this compound is oral. At the molecular level, guanfacine interacts with two recorded protein targets. It functions as an agonist or binder of the Alpha-2A adrenergic receptor (ADRA2A) and the Alpha-2B adrenergic receptor (ADRA2B). Human Neurotoxin C9H9Cl2N3O 246.093 245.012267339 N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide guanfacine 29110-47-2 NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15) INJOMKTZOLKMBF-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Halobenzenes Dichlorobenzenes Aryl chlorides Carboximidamides Hydrocarbon derivatives Imines Organochlorides Organooxygen compounds Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds 1,3-dichlorobenzene Aromatic homomonocyclic compound Aryl chloride Aryl halide Carboximidamide Hydrocarbon derivative Imine Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organochloride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Aromatic homomonocyclic compounds acetamides Detected and Not Quantified Guanfacine Drug Metabolism Action Pathway SMP0143448 logp 1.74 logp 2.28 ALOGPS logs -3.25 ALOGPS solubility 1.39e-01 g/l ALOGPS logp 1.74 ChemAxon pka_strongest_acidic 12.94 ChemAxon pka_strongest_basic 6.65 ChemAxon iupac N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide ChemAxon average_mass 246.093 ChemAxon mono_mass 245.012267339 ChemAxon smiles NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl ChemAxon formula C9H9Cl2N3O ChemAxon inchi InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15) ChemAxon inchikey INJOMKTZOLKMBF-UHFFFAOYSA-N ChemAxon polar_surface_area 78.97 ChemAxon refractivity 69.63 ChemAxon polarizability 21.75 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 3 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726c4e6188> DB01018 3519 3399 BE0000289 BE0000572