1.0 2016-05-25 18:25:46 UTC 2026-08-20 00:45:41 UTC Cyclizine SmallMolecule Cyclizine is an organic compound with the formula C18H22N2 and an average molecular weight of 266.38 g/mol. Cyclizine belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds. This compound is associated with six recorded sources, including healthcare, pharmaceuticals and veterinary products as antihistamines, as well as indoor air within air, dust and atmospheric transport. Other sources include household cleaning and consumer products, specifically tobacco smoke filters and non electric simulated smoking devices, and electrical and electronic equipment, such as electrically stimulated smoking devices and electric hearing aids. Recorded exposure routes for cyclizine include oral, intravenous, intramuscular, and inhalation. In terms of biological activity, cyclizine has two recorded protein targets. It acts as an antagonist or inhibitor of the Histamine H1 receptor (HRH1) and Sulfotransferase 1E1 (SULT1E1). Human Neurotoxin C18H22N2 266.3807 266.178298714 1-(diphenylmethyl)-4-methylpiperazine cyclizine 82-92-8 CN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1 InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3 UVKZSORBKUEBAZ-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes Diphenylmethanes Aralkylamines Azacyclic compounds Hydrocarbon derivatives N-methylpiperazines Organopnictogen compounds Trialkylamines 1,4-diazinane Amine Aralkylamine Aromatic heteromonocyclic compound Azacycle Diphenylmethane Hydrocarbon derivative N-alkylpiperazine N-methylpiperazine Organic nitrogen compound Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Piperazine Tertiary aliphatic amine Tertiary amine Aromatic heteromonocyclic compounds N-alkylpiperazine Detected and Not Quantified Cyclizine H1-Antihistamine Action SMP0058923 Cyclizine Drug Metabolism Action Pathway SMP0143595 Cyclizine H1 Antihistamine Neurological Sleep Action Pathway SMP0145418 Cyclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway SMP0174904 Cyclizine H1-Antihistamine Blood Vessel Constriction Action Pathway SMP0174996 Cyclizine H1-Antihistamine Immune Response Action Pathway SMP0175088 logp 3.55 logp 3.55 ALOGPS logs -3.55 ALOGPS solubility 7.52e-02 g/l ALOGPS logp 3.55 ChemAxon pka_strongest_basic 8.51 ChemAxon iupac 1-(diphenylmethyl)-4-methylpiperazine ChemAxon average_mass 266.3807 ChemAxon mono_mass 266.178298714 ChemAxon smiles CN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1 ChemAxon formula C18H22N2 ChemAxon inchi InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3 ChemAxon inchikey UVKZSORBKUEBAZ-UHFFFAOYSA-N ChemAxon polar_surface_area 6.48 ChemAxon refractivity 84.93 ChemAxon polarizability 31.53 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf8bfdca0> DB01176 6726 6470 BE0000442 BE0000951