1.0 2016-05-25 18:26:06 UTC 2026-08-19 04:10:23 UTC Dantrolene SmallMolecule Dantrolene is an organic compound with the chemical formula C14H10N4O5 and an average molecular weight of 314.26 g/mol. Dantrolene belongs to the imidazolidines, a subclass of azolidines within the organic compounds. In terms of biological activity, it acts as an antagonist of the Ryanodine receptor 1 (RYR1). The substance is associated with six recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is used as a muscle relaxant. Other recorded sources include drinking water and water supply, food preservation in food processing and cookware, and tobacco smoke filters in household cleaning and consumer products. Additionally, it is found in electrical and electronic equipment, specifically antennas and electrically stimulated smoking devices. Exposure to this compound occurs through oral and intravenous routes. C14H10N4O5 314.257 314.065119438 4-hydroxy-1-[(E)-{[5-(4-nitrophenyl)furan-2-yl]methylidene}amino]-2,5-dihydro-1H-imidazol-2-one 4-hydroxy-1-[(E)-{[5-(4-nitrophenyl)furan-2-yl]methylidene}amino]-5H-imidazol-2-one 7261-97-4 [H]\C(=N/N1CC(O)=NC1=O)C1=CC=C(O1)C1=CC=C(C=C1)N(=O)=O InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/b15-7+ OZOMQRBLCMDCEG-VIZOYTHASA-N Organic compounds Organoheterocyclic compounds Azolidines Imidazolidines Hydantoins Alpha amino acids and derivatives Azacyclic compounds Carbonyl compounds Dicarboximides Furans Heteroaromatic compounds Hydrocarbon derivatives Nitroaromatic compounds Nitrobenzenes Organic carbonic acids and derivatives Organic oxides Organic oxoazanium compounds Organic zwitterions Organopnictogen compounds Oxacyclic compounds Propargyl-type 1,3-dipolar organic compounds Semicarbazones Allyl-type 1,3-dipolar organic compound Alpha-amino acid or derivatives Aromatic heteromonocyclic compound Azacycle Benzenoid C-nitro compound Carbonic acid derivative Carbonyl group Carboxylic acid derivative Dicarboximide Furan Heteroaromatic compound Hydantoin Hydrocarbon derivative Monocyclic benzene moiety Nitroaromatic compound Nitrobenzene Organic 1,3-dipolar compound Organic nitro compound Organic nitrogen compound Organic oxide Organic oxoazanium Organic oxygen compound Organic zwitterion Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Propargyl-type 1,3-dipolar organic compound Semicarbazide Semicarbazone Aromatic heteromonocyclic compounds Detected and Not Quantified Dantrolene Drug Metabolism Action Pathway SMP0143637 logp 1.26 logp 1.47 ALOGPS logs -3.69 ALOGPS solubility 6.45e-02 g/l ALOGPS logp 1.62 ChemAxon pka_strongest_acidic 5.19 ChemAxon pka_strongest_basic -1.6 ChemAxon iupac 4-hydroxy-1-[(E)-{[5-(4-nitrophenyl)furan-2-yl]methylidene}amino]-2,5-dihydro-1H-imidazol-2-one ChemAxon average_mass 314.257 ChemAxon mono_mass 314.065119438 ChemAxon smiles [H]\C(=N/N1CC(O)=NC1=O)C1=CC=C(O1)C1=CC=C(C=C1)N(=O)=O ChemAxon formula C14H10N4O5 ChemAxon inchi InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/b15-7+ ChemAxon inchikey OZOMQRBLCMDCEG-VIZOYTHASA-N ChemAxon polar_surface_area 124.22 ChemAxon refractivity 79.2 ChemAxon polarizability 30.09 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 6 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7225f27940> DB01219 2952 5290202 BE0000739