1.0 2016-05-25 18:26:49 UTC 2026-08-18 23:28:57 UTC Ceftizoxime SmallMolecule Ceftizoxime is an organic compound with the formula C13H13N5O5S2 and an average molecular weight of 383.40 g/mol. Ceftizoxime belongs to the beta lactams, a subclass of lactams within the organic compounds. It is further categorized as an organoheterocyclic compound. The compound is found in or released from four recorded sources: healthcare, pharmaceuticals & veterinary products (specifically antibiotics and beta-lactam antibacterials), electrical & electronic equipment (video games), and household cleaning & consumer products (other smoking requisites). Recorded exposure routes for this substance include oral, intravenous, intramuscular, and inhalation. At the molecular level, ceftizoxime interacts with three recorded protein targets. It acts as a binder or inhibitor of penicillin-binding protein 1A (mrcA) and penicillin-binding protein 1B (mrcB). Additionally, it targets D-alanyl-D-alanine carboxypeptidase DacC (dacC). C13H13N5O5S2 383.403 383.035809931 (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ceftizoxime 68401-81-0 [H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1 NNULBSISHYWZJU-LLKWHZGFSA-N Organic compounds Organoheterocyclic compounds Lactams Beta lactams Cephalosporins 1,3-thiazines 2,4-disubstituted thiazoles 2-amino-1,3-thiazoles Amino acids Azacyclic compounds Azetidines Carbonyl compounds Carboxylic acids Dialkylthioethers Heteroaromatic compounds Hydrocarbon derivatives Monocarboxylic acids and derivatives N-acyl-alpha amino acids and derivatives Organic oxides Organopnictogen compounds Primary amines Secondary carboxylic acid amides Tertiary carboxylic acid amides Thiohemiaminal derivatives 1,3-thiazol-2-amine 2,4-disubstituted 1,3-thiazole Alpha-amino acid or derivatives Amine Amino acid Amino acid or derivatives Aromatic heteropolycyclic compound Azacycle Azetidine Azole Carbonyl group Carboxamide group Carboxylic acid Carboxylic acid derivative Cephalosporin Dialkylthioether Hemithioaminal Heteroaromatic compound Hydrocarbon derivative Meta-thiazine Monocarboxylic acid or derivatives N-acyl-alpha amino acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary amine Secondary carboxylic acid amide Tertiary carboxylic acid amide Thiazole Thioether Aromatic heteropolycyclic compounds cephalosporin Detected and Not Quantified Ceftizoxime Drug Metabolism Action Pathway SMP0143712 logp -0.94 logp 0.40 ALOGPS logs -3.22 ALOGPS solubility 2.29e-01 g/l ALOGPS logp -0.85 ChemAxon pka_strongest_acidic 3.13 ChemAxon pka_strongest_basic 4.16 ChemAxon iupac (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ChemAxon average_mass 383.403 ChemAxon mono_mass 383.035809931 ChemAxon smiles [H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O ChemAxon formula C13H13N5O5S2 ChemAxon inchi InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1 ChemAxon inchikey NNULBSISHYWZJU-LLKWHZGFSA-N ChemAxon polar_surface_area 147.21 ChemAxon refractivity 89.9 ChemAxon polarizability 35.38 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 8 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7272a221c8> DB01332 6533629 5018818 BE0000588 BE0000488 BE0003685