1.0 2016-05-25 18:27:57 UTC 2026-08-22 00:50:32 UTC Solifenacin SmallMolecule Solifenacin is an organic compound with the chemical formula C27H32N2O6 and an average molecular weight of 480.55 g/mol. Solifenacin belongs to the 1-phenyltetrahydroisoquinolines, a subclass of tetrahydroisoquinolines within the organic compounds. This compound is categorized under the superclass of organoheterocyclic compounds. The substance is found in or released from three recorded sources, including household cleaning and consumer products specifically listed as other smoking requisites, as well as healthcare, pharmaceuticals, and veterinary products, where it is used as a drug for benign prostatic hypertrophy and among urologicals. The recorded route of exposure for this compound is oral. Solifenacin interacts with five recorded protein targets. It acts as an antagonist for the muscarinic acetylcholine receptor M1 (CHRM1), muscarinic acetylcholine receptor M2 (CHRM2), muscarinic acetylcholine receptor M3 (CHRM3), and muscarinic acetylcholine receptor M4 (CHRM4), in addition to one other protein. C27H32N2O6 480.5528 480.226036766 (3R)-1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; butanedioic acid solifenacin; succinic acid 242478-37-1 OC(=O)CCC(O)=O.O=C(O[C@H]1CN2CCC1CC2)N1CCC2=CC=CC=C2[C@@H]1C1=CC=CC=C1 InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1 RXZMMZZRUPYENV-VROPFNGYSA-N Organic compounds Organoheterocyclic compounds Tetrahydroisoquinolines 1-phenyltetrahydroisoquinolines 1-phenyltetrahydroisoquinolines Azacyclic compounds Benzene and substituted derivatives Carbamate esters Carbonyl compounds Dicarboxylic acids and derivatives Hydrocarbon derivatives Organic carbonic acids and derivatives Organic oxides Organopnictogen compounds Piperidines Quinuclidines Trialkylamines 1-phenyltetrahydroisoquinoline Amine Aromatic heteropolycyclic compound Azacycle Benzenoid Carbamic acid ester Carbonic acid derivative Carbonyl group Dicarboxylic acid or derivatives Hydrocarbon derivative Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Piperidine Quinuclidine Tertiary aliphatic amine Tertiary amine Detected and Not Quantified Solifenacin M3 Bladder Muscle Relaxation Action Pathway SMP0126383 Solifenacin Drug Metabolism Action Pathway SMP0143792 logp 3.96 logp 3.96 ChemAxon pka_strongest_basic 8.88 ChemAxon iupac (3R)-1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; butanedioic acid ChemAxon average_mass 480.5528 ChemAxon mono_mass 480.226036766 ChemAxon smiles OC(=O)CCC(O)=O.O=C(O[C@H]1CN2CCC1CC2)N1CCC2=CC=CC=C2[C@@H]1C1=CC=CC=C1 ChemAxon formula C27H32N2O6 ChemAxon inchi InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1 ChemAxon inchikey RXZMMZZRUPYENV-VROPFNGYSA-N ChemAxon polar_surface_area 32.78 ChemAxon refractivity 106.06 ChemAxon polarizability 40.52 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226a728b8> DB01591 154059 BE0000045 BE0000092 BE0000560 BE0000405 BE0000247