1.0 2016-05-25 18:28:25 UTC 2026-08-19 16:33:02 UTC Pheniramine SmallMolecule Pheniramine is an organic compound with the formula C16H20N2 and an average molecular weight of 240.34 g/mol. Pheniramine belongs to the pheniramines, a subclass of pyridines and derivatives within the organic compounds. This substance is categorized as an organoheterocyclic compound. The compound is found in or released from seven recorded sources. These include healthcare, pharmaceuticals, and veterinary products, specifically antihistamines and antipruritics. It is also associated with household cleaning and consumer products, such as cigar cigarettes and other smoking requisites, as well as electrical and electronic equipment, including relays and electrically stimulated smoking devices. Additionally, it is found in building and construction materials, specifically fencing. Recorded exposure routes for pheniramine include oral, ophthalmic, and nasal pathways. At the molecular level, pheniramine interacts with three recorded protein targets. It acts as an agonist or inverse agonist of the histamine H1 receptor (HRH1) and the histamine H4 receptor (HRH4), as well as the nuclear receptor subfamily 1 group I member 3 (NR1I3). Human Neurotoxin C16H20N2 240.3434 240.16264865 dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine pheniramine 86-21-5 CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=N1 InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3 IJHNSHDBIRRJRN-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Pyridines and derivatives Pheniramines Pheniramines Aralkylamines Azacyclic compounds Benzene and substituted derivatives Heteroaromatic compounds Hydrocarbon derivatives Organopnictogen compounds Trialkylamines Amine Aralkylamine Aromatic heteromonocyclic compound Azacycle Benzenoid Heteroaromatic compound Hydrocarbon derivative Monocyclic benzene moiety Organic nitrogen compound Organonitrogen compound Organopnictogen compound Pheniramine Tertiary aliphatic amine Tertiary amine Aromatic heteromonocyclic compounds Detected and Not Quantified Pheniramine H1-Antihistamine Action SMP0056662 Pheniramine Drug Metabolism Action Pathway SMP0143816 Pheniramine H1 Antihistamine Neurological Sleep Action Pathway SMP0145419 Pheniramine Predicted Metabolism Pathway SMP0174551 Pheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway SMP0174907 Pheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway SMP0174999 Pheniramine H1-Antihistamine Immune Response Action Pathway SMP0175091 logp 2.98 logp 2.85 ALOGPS logs -2.80 ALOGPS solubility 3.77e-01 g/l ALOGPS logp 2.98 ChemAxon pka_strongest_basic 9.48 ChemAxon iupac dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine ChemAxon average_mass 240.3434 ChemAxon mono_mass 240.16264865 ChemAxon smiles CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=N1 ChemAxon formula C16H20N2 ChemAxon inchi InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3 ChemAxon inchikey IJHNSHDBIRRJRN-UHFFFAOYSA-N ChemAxon polar_surface_area 16.13 ChemAxon refractivity 76.05 ChemAxon polarizability 28.41 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3baf1d8de0> DB01620 4761 4597 BE0000442 BE0003848 BE0000146