1.0 2016-05-26 05:32:33 UTC 2026-08-17 23:40:51 UTC Cyclic GMP SmallMolecule Cyclic GMP is an organic compound with the formula C10H12N5O7P and an average molecular weight of 345.21 g/mol. Cyclic GMP belongs to the cyclic purine nucleotides, a subclass of purine nucleotides within the organic compounds. It is classified under the superclass of nucleosides, nucleotides, and analogues. This compound has been recorded as being found in or released from electrical and electronic equipment antennas. In biological systems, it interacts with three recorded protein targets: the cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A), the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2), and it acts as an inhibitor of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A). cyclic-GMP C10H12N5O7P 345.2053 345.047434275 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-hexahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-6,9-dihydro-1H-purin-6-one cyclic-GMP 7665-99-8 NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@H]3[C@H]2O)C(=O)N1 InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N Organic compounds Nucleosides, nucleotides, and analogues Purine nucleotides Cyclic purine nucleotides 3',5'-cyclic purine nucleotides 6-oxopurines Aminopyrimidines and derivatives Azacyclic compounds Glycosylamines Heteroaromatic compounds Hydrocarbon derivatives Hypoxanthines Monosaccharide phosphates N-substituted imidazoles Organic oxides Organic phosphoric acids and derivatives Organopnictogen compounds Oxacyclic compounds Pentose phosphates Primary amines Pyrimidones Secondary alcohols Tetrahydrofurans Vinylogous amides 3',5'-cyclic purine ribonucleotide 6-oxopurine Alcohol Amine Aminopyrimidine Aromatic heteropolycyclic compound Azacycle Azole Glycosyl compound Heteroaromatic compound Hydrocarbon derivative Hypoxanthine Imidazole Imidazopyrimidine Monosaccharide Monosaccharide phosphate N-glycosyl compound N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organic phosphoric acid derivative Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Pentose phosphate Primary amine Purine Purinone Pyrimidine Pyrimidone Secondary alcohol Tetrahydrofuran Vinylogous amide Aromatic heteropolycyclic compounds 3',5'-Cyclic nuclcleotides 3',5'-cyclic purine nucleotide guanyl ribonucleotide Detected and Not Quantified logp -2.1 logp -1.98 ALOGPS logs -1.96 ALOGPS solubility 3.79e+00 g/l ALOGPS logp -2.1 ChemAxon pka_strongest_acidic 2.05 ChemAxon pka_strongest_basic 1.41 ChemAxon iupac 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-hexahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-6,9-dihydro-1H-purin-6-one ChemAxon average_mass 345.2053 ChemAxon mono_mass 345.047434275 ChemAxon smiles NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@H]3[C@H]2O)C(=O)N1 ChemAxon formula C10H12N5O7P ChemAxon inchi InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1 ChemAxon inchikey ZOOGRGPOEVQQDX-UUOKFMHZSA-N ChemAxon polar_surface_area 170.52 ChemAxon refractivity 71.72 ChemAxon polarizability 29.19 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 8 ChemAxon donor_count 4 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7227e48900> DB02315 135398570 BE0002085 BE0004631 BE0003425