1.0 2016-05-26 06:42:54 UTC 2026-08-21 22:56:20 UTC Sildenafil SmallMolecule Sildenafil is an organic compound with the formula C22H30N6O4S and an average molecular weight of 474.58 g/mol. Sildenafil belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. This compound is associated with four recorded sources, including antennas in electrical and electronic equipment, drinking water in drinking water and water supply, and gynecologicals and urologicals in healthcare, pharmaceuticals and veterinary products. Recorded exposure routes for this substance include oral and intravenous administration. Sildenafil interacts with six recorded protein targets. It acts as a modulator, inhibitor, or downregulator of cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A). Additional protein targets include ornithine decarboxylase (ODC1), retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6H), and retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6G), as well as two other proteins. C22H30N6O4S 474.576 474.204924168 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one revatio 139755-83-2 CCCC1=NN(C)C2=C1NC(=NC2=O)C1=C(OCC)C=CC(=C1)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) BNRNXUUZRGQAQC-UHFFFAOYSA-N Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Benzenesulfonamides Alkyl aryl ethers Azacyclic compounds Benzenesulfonyl compounds Heteroaromatic compounds Hydrocarbon derivatives Lactams N-methylpiperazines Organic oxides Organopnictogen compounds Organosulfonamides Phenol ethers Phenoxy compounds Pyrazoles Pyrazolopyrimidines Pyrimidones Sulfonyls Trialkylamines 1,4-diazinane Alkyl aryl ether Amine Aromatic heteropolycyclic compound Azacycle Azole Benzenesulfonamide Benzenesulfonyl group Ether Heteroaromatic compound Hydrocarbon derivative Lactam N-alkylpiperazine N-methylpiperazine Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Phenol ether Phenoxy compound Piperazine Pyrazole Pyrazolopyrimidine Pyrimidine Pyrimidone Sulfonyl Tertiary aliphatic amine Tertiary amine Aromatic heteropolycyclic compounds piperazines pyrazolopyrimidine sulfonamide Detected and Not Quantified Sildenafil Action Pathway SMP0124685 Sildenafil Drug Metabolism Action Pathway SMP0142666 logp 1.87 logp 2.35 ALOGPS logs -3.04 ALOGPS solubility 4.33e-01 g/l ALOGPS logp 1.65 ChemAxon pka_strongest_acidic 7.27 ChemAxon pka_strongest_basic 5.97 ChemAxon iupac 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one ChemAxon average_mass 474.576 ChemAxon mono_mass 474.204924168 ChemAxon smiles CCCC1=NN(C)C2=C1NC(=NC2=O)C1=C(OCC)C=CC(=C1)S(=O)(=O)N1CCN(C)CC1 ChemAxon formula C22H30N6O4S ChemAxon inchi InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) ChemAxon inchikey BNRNXUUZRGQAQC-UHFFFAOYSA-N ChemAxon polar_surface_area 109.13 ChemAxon refractivity 139.44 ChemAxon polarizability 51.18 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 8 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72227fe1a8> DB00203 5212 5023 BE0000182 BE0003556 BE0003557 BE0000404 BE0003441 BE0002458