1.0 2016-06-03 11:01:42 UTC 2026-08-19 02:08:35 UTC articaine SmallMolecule Articaine is an organic compound with the chemical formula C13H20N2O3S and an average molecular weight of 284.37 g/mol. Articaine belongs to the thiophene carboxylic acids and derivatives, a subclass of thiophenes within the organic compounds. It is categorized as an organoheterocyclic compound. The compound is found in or released from four recorded sources: pharmaceuticals & veterinary products specifically as anesthetics, electrically stimulated smoking devices within electrical & electronic equipment, the preparation of wine or sparkling wine in food, food processing & cookware, and non electric simulated smoking devices in household cleaning & consumer products. Recorded exposure routes for articaine include dental, infiltration, ophthalmic, subcutaneous, and submucosal administration. At a molecular level, articaine interacts with ten recorded protein targets. It acts as an inhibitor of sodium channel protein type 1 subunit alpha (SCN1A), sodium channel protein type 4 subunit alpha (SCN4A), sodium channel protein type 5 subunit alpha (SCN5A), and sodium channel protein type 7 subunit alpha (SCN7A), in addition to six other proteins. Human Neurotoxin C13H20N2O3S 284.374 284.119463206 N-[2-(methoxycarbonyl)-4-methylthiophen-3-yl]-2-(propylamino)propanimidic acid carticaine 23964-58-1 CCCNC(C)C(O)=NC1=C(SC=C1C)C(=O)OC InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16) QTGIAADRBBLJGA-UHFFFAOYSA-N Organic compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives Thiophene carboxylic acids and derivatives Amino acids and derivatives Carboximidic acids Dialkylamines Heteroaromatic compounds Hydrocarbon derivatives Methyl esters Monocarboxylic acids and derivatives Organic oxides Organooxygen compounds Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Amine Amino acid or derivatives Aromatic heteromonocyclic compound Carboximidic acid Carboximidic acid derivative Carboxylic acid derivative Carboxylic acid ester Heteroaromatic compound Hydrocarbon derivative Methyl ester Monocarboxylic acid or derivatives Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Secondary aliphatic amine Secondary amine Thiophene carboxylic acid or derivatives Aromatic heteromonocyclic compounds Detected and Not Quantified Articaine Drug Metabolism Action Pathway SMP0144252 logp 3.25 logp 1.90 ALOGPS logs -3.89 ALOGPS solubility 3.66e-02 g/l ALOGPS logp 0.96 ChemAxon pka_strongest_acidic 4.42 ChemAxon pka_strongest_basic 8.91 ChemAxon iupac N-[2-(methoxycarbonyl)-4-methylthiophen-3-yl]-2-(propylamino)propanimidic acid ChemAxon average_mass 284.374 ChemAxon mono_mass 284.119463206 ChemAxon smiles CCCNC(C)C(O)=NC1=C(SC=C1C)C(=O)OC ChemAxon formula C13H20N2O3S ChemAxon inchi InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16) ChemAxon inchikey QTGIAADRBBLJGA-UHFFFAOYSA-N ChemAxon polar_surface_area 70.92 ChemAxon refractivity 77.53 ChemAxon polarizability 30.8 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726da2df28> DB09009 32170 29837 BE0000141 BE0002083 BE0004901 BE0000197 BE0001143 BE0002081 BE0002082 BE0000192 BE0002084 BE0000177