1.0 2016-06-03 11:03:25 UTC 2026-05-14 16:38:45 UTC Ceftazidime SmallMolecule Ceftazidime is an organoheterocyclic compound with the chemical formula C22H22N6O7S2. Ceftazidime belongs to the beta lactams, a subclass of lactams within the organic compounds. With an average molecular weight of 546.58 g/mol, Ceftazidime is a heavy molecule. The compound is found in or released from three recorded sources, including antennas from electrical and electronic equipment, as well as antibiotics and beta-lactam antibacterials from pharmaceuticals, veterinary products, and healthcare. Exposure routes for the substance include oral, intravenous, intramuscular, and inhalation. Ceftazidime interacts with five recorded protein targets. It serves as an inhibitor or substrate for Penicillin-binding protein 1A (mrcA), Penicillin-binding protein 1B (mrcB), Peptidoglycan D,D-transpeptidase FtsI (ftsI), and Peptidoglycan D,D-transpeptidase MrdA (mrdA), in addition to one other protein. C22H22N6O7S2 546.576 546.099138468 1-{[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}pyridin-1-ium ceftazidime 72558-82-8 [O-]C(=O)C1=C(CS[C@]2([H])[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C3=CSC(N)=N3)C(=O)N12)C[N+]1=CC=CC=C1 InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1 ORFOPKXBNMVMKC-DWVKKRMSSA-N Organic compounds Organoheterocyclic compounds Lactams Beta lactams Cephalosporins 1,3-thiazines 2,4-disubstituted thiazoles 2-amino-1,3-thiazoles Amino acids Azacyclic compounds Azetidines Carbonyl compounds Carboxylic acid salts Carboxylic acids Dialkylthioethers Dicarboxylic acids and derivatives Heteroaromatic compounds Hydrocarbon derivatives N-acyl-alpha amino acids and derivatives Organic oxides Organic salts Organic zwitterions Organopnictogen compounds Primary amines Pyridinium derivatives Secondary carboxylic acid amides Tertiary carboxylic acid amides Thiohemiaminal derivatives 1,3-thiazol-2-amine 2,4-disubstituted 1,3-thiazole Alpha-amino acid or derivatives Amine Amino acid Amino acid or derivatives Aromatic heteropolycyclic compound Azacycle Azetidine Azole Carbonyl group Carboxamide group Carboxylic acid Carboxylic acid derivative Carboxylic acid salt Cephalosporin Dialkylthioether Dicarboxylic acid or derivatives Hemithioaminal Heteroaromatic compound Hydrocarbon derivative Meta-thiazine N-acyl-alpha amino acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organic salt Organic zwitterion Organonitrogen compound Organooxygen compound Organopnictogen compound Primary amine Pyridine Pyridinium Secondary carboxylic acid amide Tertiary carboxylic acid amide Thiazole Thioether Aromatic heteropolycyclic compounds cephalosporin oxime O-ether Detected and Not Quantified Ceftazidime Drug Metabolism Action Pathway SMP0142895 logp -4.2 logp -1.21 ALOGPS logs -5.02 ALOGPS solubility 5.73e-03 g/l ALOGPS logp -4.1 ChemAxon pka_strongest_acidic 2.77 ChemAxon pka_strongest_basic 4.26 ChemAxon iupac 1-{[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}pyridin-1-ium ChemAxon average_mass 546.576 ChemAxon mono_mass 546.099138468 ChemAxon smiles [O-]C(=O)C1=C(CS[C@]2([H])[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C3=CSC(N)=N3)C(=O)N12)C[N+]1=CC=CC=C1 ChemAxon formula C22H22N6O7S2 ChemAxon inchi InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1 ChemAxon inchikey ORFOPKXBNMVMKC-DWVKKRMSSA-N ChemAxon polar_surface_area 191.22 ChemAxon refractivity 143.88 ChemAxon polarizability 51.06 ChemAxon rotatable_bond_count 9 ChemAxon acceptor_count 10 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7244017f80> DB00438 73415817 4587145 BE0002393 BE0000588 BE0000488 BE0003579 BE0001755