1.0 2016-06-03 11:12:04 UTC 2026-05-14 17:08:21 UTC dihydrocodeine SmallMolecule Dihydrocodeine is an organic compound with the formula C18H23NO3 and an average molecular weight of 301.38 g/mol. Dihydrocodeine belongs to the morphinans, a class of alkaloids and derivatives within the organic compounds. This compound is found in or released from three recorded sources: drinking water and water supply (drinking water), healthcare, pharmaceuticals and veterinary products (analgesics), and household cleaning and consumer products (non electric simulated smoking devices). The recorded exposure route for dihydrocodeine is oral. Regarding its biological activity, one protein target has been recorded: it acts as an antagonist of the Mu-type opioid receptor (OPRM1). C18H23NO3 301.3801 301.167793607 (1S,5R,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-ol dihydrocodeine 125-28-0 [H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])CC[C@@H]2O InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1 RBOXVHNMENFORY-DNJOTXNNSA-N Organic compounds Alkaloids and derivatives Morphinans Morphinans Alkyl aryl ethers Anisoles Aralkylamines Azacyclic compounds Coumarans Cyclic alcohols and derivatives Hydrocarbon derivatives Organopnictogen compounds Oxacyclic compounds Phenanthrenes and derivatives Piperidines Secondary alcohols Tetralins Trialkylamines Alcohol Alkyl aryl ether Amine Anisole Aralkylamine Aromatic heteropolycyclic compound Azacycle Benzenoid Coumaran Cyclic alcohol Ether Hydrocarbon derivative Morphinan Organic nitrogen compound Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Phenanthrene Piperidine Secondary alcohol Tertiary aliphatic amine Tertiary amine Tetralin Aromatic heteropolycyclic compounds Detected and Not Quantified Dihydrocodeine Opioid Agonist Action Pathway SMP0124998 Remifentanil Opioid Anasthetic Action Pathway SMP0125022 Dihydrocodeine Drug Metabolism Action Pathway SMP0143774 logp 1.55 logp 1.58 ALOGPS logs -2.10 ALOGPS solubility 2.38e+00 g/l ALOGPS logp 1.55 ChemAxon pka_strongest_acidic 14.15 ChemAxon pka_strongest_basic 9.33 ChemAxon iupac (1S,5R,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-ol ChemAxon average_mass 301.3801 ChemAxon mono_mass 301.167793607 ChemAxon smiles [H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])CC[C@@H]2O ChemAxon formula C18H23NO3 ChemAxon inchi InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1 ChemAxon inchikey RBOXVHNMENFORY-DNJOTXNNSA-N ChemAxon polar_surface_area 41.93 ChemAxon refractivity 83.64 ChemAxon polarizability 32.82 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7221a3d0c8> DB01551 5284543 4447600 BE0000770