1.0 2016-06-03 11:29:24 UTC 2026-08-22 08:24:17 UTC lasofoxifene SmallMolecule Lasofoxifene is an organic compound with the formula C28H31NO2 and an average molecular weight of 413.55 g/mol. It belongs to the phenylnaphthalenes, a subclass of naphthalenes within the organic compounds. This substance is associated with healthcare, pharmaceuticals, and veterinary products, specifically as a sex hormone and modulator of the genital system, and is administered via the oral exposure route. The compound interacts with four recorded protein targets. It acts as an agonist, antagonist, negative modulator, inverse agonist, or modulator of the Estrogen receptor (ESR1), Estrogen receptor beta (ESR2), Cannabinoid receptor 2 (CNR2), and Fusion glycoprotein F0. C28H31NO2 413.5512 413.235479241 (5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol lasofoxifene 180916-16-9 [H][C@@]1(CCC2=CC(O)=CC=C2[C@@]1([H])C1=CC=C(OCCN2CCCC2)C=C1)C1=CC=CC=C1 InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1 GXESHMAMLJKROZ-IAPPQJPRSA-N Organic compounds Benzenoids Naphthalenes Phenylnaphthalenes Phenylnaphthalenes 1-hydroxy-2-unsubstituted benzenoids Alkyl aryl ethers Azacyclic compounds Hydrocarbon derivatives N-alkylpyrrolidines Organopnictogen compounds Phenol ethers Phenoxy compounds Stilbenes Tetralins Trialkylamines 1-hydroxy-2-unsubstituted benzenoid Alkyl aryl ether Amine Aromatic heteropolycyclic compound Azacycle Ether Hydrocarbon derivative Monocyclic benzene moiety N-alkylpyrrolidine Organic nitrogen compound Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenol ether Phenoxy compound Phenylnaphthalene Pyrrolidine Stilbene Tertiary aliphatic amine Tertiary amine Tetralin Aromatic heteropolycyclic compounds N-alkylpyrrolidine naphthols Detected and Not Quantified Lasofoxifene Drug Metabolism Action Pathway SMP0144005 logp 5.97 logp 6.36 ALOGPS logs -6.02 ALOGPS solubility 3.98e-04 g/l ALOGPS logp 5.97 ChemAxon pka_strongest_acidic 10.21 ChemAxon pka_strongest_basic 8.98 ChemAxon iupac (5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol ChemAxon average_mass 413.5512 ChemAxon mono_mass 413.235479241 ChemAxon smiles [H][C@@]1(CCC2=CC(O)=CC=C2[C@@]1([H])C1=CC=C(OCCN2CCCC2)C=C1)C1=CC=CC=C1 ChemAxon formula C28H31NO2 ChemAxon inchi InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1 ChemAxon inchikey GXESHMAMLJKROZ-IAPPQJPRSA-N ChemAxon polar_surface_area 32.7 ChemAxon refractivity 126.83 ChemAxon polarizability 47.58 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726c728360> DB06202 216416 187585 BE0000123 BE0000792 BE0000095 BE0010205