1.0 2016-06-03 11:58:58 UTC 2026-08-21 22:47:50 UTC fluocortolone SmallMolecule Fluocortolone is an organic compound with the chemical formula C22H29FO4 and an average molecular weight of 376.46 g/mol. It is classified as follows: fluocortolone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This substance has been identified in or released from 26 recorded sources across various sectors. In aquatic systems and sediments, it is found in groundwater, surface water, seawater, and freshwater. It is also present in drinking water and water supply sources, including tap water, bottled water, and desalinated water. Within wastewater, sanitation, and biosolids, it appears in industrial wastewater, wastewater treatment effluent, mine wastewater, and unspecified wastewater. Fluocortolone is associated with several household cleaning and consumer products, specifically perfumes within detergents and soaps, cigar cigarettes, tobacco smoke filters, and non electric simulated smoking devices. It has also been detected in electrical and electronic equipment, such as radio transmission systems, hybrid capacitors, and antennas, as well as in appliances, HVAC, and refrigerants, including water heaters and water coolers. Additionally, it is found in four other sectors. Recorded routes of exposure for this compound include oral, inhalation, and touch. PMT C22H29FO4 376.4617 376.204987621 (1S,2R,8S,10S,11S,13R,14S,15S,17S)-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one fluocortolone 152-97-6 [H][C@@]1(C)C[C@@]2([H])[C@]3([H])C[C@]([H])(F)C4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]2(C)[C@@]1([H])C(=O)CO InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1 GAKMQHDJQHZUTJ-ULHLPKEOSA-N Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids 21-hydroxysteroids 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Gluco/mineralocorticoids, progestogins and derivatives Halogenated steroids Hydrocarbon derivatives Organic oxides Organofluorides Primary alcohols Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 6-halo-steroid Alcohol Aliphatic homopolycyclic compound Alkyl fluoride Alkyl halide Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Halo-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Aliphatic homopolycyclic compounds Detected and Not Quantified Fluocortolone Drug Metabolism Action Pathway SMP0144244 logp 1.97 logp 2.09 ALOGPS logs -4.05 ALOGPS solubility 3.39e-02 g/l ALOGPS logp 1.97 ChemAxon pka_strongest_acidic 13.84 ChemAxon pka_strongest_basic -0.23 ChemAxon iupac (1S,2R,8S,10S,11S,13R,14S,15S,17S)-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one ChemAxon average_mass 376.4617 ChemAxon mono_mass 376.204987621 ChemAxon smiles [H][C@@]1(C)C[C@@]2([H])[C@]3([H])C[C@]([H])(F)C4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]2(C)[C@@]1([H])C(=O)CO ChemAxon formula C22H29FO4 ChemAxon inchi InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1 ChemAxon inchikey GAKMQHDJQHZUTJ-ULHLPKEOSA-N ChemAxon polar_surface_area 74.6 ChemAxon refractivity 101.47 ChemAxon polarizability 40.07 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72220a8340> DB08971 9053 8701