1.0 2017-01-04 16:47:52 UTC 2026-08-19 06:29:41 UTC Trimethoprim SmallMolecule Trimethoprim is an organic compound with the formula C14H18N4O3 and an average molecular weight of 290.32 g/mol. Trimethoprim belongs to the anisoles, a subclass of phenol ethers within the organic compounds. Biologically, it functions as an antibacterial agent (PMC5785760) and an inhibitor (PMC5350610). It serves as a treatment for pneumonia (PMC10922816). The compound acts as an inhibitor or modulator of the protein targets Dihydrofolate reductase (folA) and Dihydrofolate reductase (DHFR). Trimethoprim is found in or released from 33 recorded sources. These include healthcare, pharmaceuticals, and veterinary products such as antibiotics, drugs for the treatment of tuberculosis, and sulfonamides and trimethoprim. It is also associated with food, food processing, and cookware, specifically the processing of meats and the preparation of malt, vinegar, wine, or sparkling wine, as well as food preservation. Other sources include drinking water, indoor air, and household cleaning and consumer products, including bleaching agents, ash trays, cigar cigarettes, other smoking requisites, and non-electric simulated smoking devices. Additionally, it is found in electrical and electronic equipment, such as electric switches, amplifiers, antennas, coils, and conductors or conductive bodies characterised by the conductive materials. Recorded exposure routes for the compound include oral, intravenous, ophthalmic, and inhalation. Human Neurotoxin C14H18N4O3 290.3177 290.137890462 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine trimethoprim 738-70-5 COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) IEDVJHCEMCRBQM-UHFFFAOYSA-N Organic compounds Benzenoids Phenol ethers Anisoles Anisoles Alkyl aryl ethers Aminopyrimidines and derivatives Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Imidolactams Methoxybenzenes Organopnictogen compounds Phenoxy compounds Primary amines Alkyl aryl ether Amine Aminopyrimidine Anisole Aromatic heteromonocyclic compound Azacycle Ether Heteroaromatic compound Hydrocarbon derivative Imidolactam Methoxybenzene Monocyclic benzene moiety Organic nitrogen compound Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenoxy compound Primary amine Pyrimidine Aromatic heteromonocyclic compounds a small molecule aminopyrimidine methoxybenzene Detected and Not Quantified Trimethoprim Drug Metabolism Action Pathway SMP0142897 Trimethoprim Predicted Metabolism Pathway SMP0174766 logp 1.28 logp 1.26 ALOGPS logs -2.67 ALOGPS solubility 6.15e-01 g/l ALOGPS logp 1.28 ChemAxon pka_strongest_acidic 17.33 ChemAxon pka_strongest_basic 7.16 ChemAxon iupac 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine ChemAxon average_mass 290.3177 ChemAxon mono_mass 290.137890462 ChemAxon smiles COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC ChemAxon formula C14H18N4O3 ChemAxon inchi InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) ChemAxon inchikey IEDVJHCEMCRBQM-UHFFFAOYSA-N ChemAxon polar_surface_area 105.51 ChemAxon refractivity 81.51 ChemAxon polarizability 29.71 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 7 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf0bac6c8> DB00440 5578 5376 BE0002010 BE0000330