1.0 2026-03-31 19:15:07 UTC 2026-08-22 08:15:15 UTC Difenoxin SmallMolecule Difenoxin is an organic compound with the formula C28H28N2O2 and an average molecular weight of 424.54 g/mol. Difenoxin belongs to the diphenylacetonitriles, a subclass of benzene and substituted derivatives within the organic compounds. It is categorized as a benzenoid. This compound acts as an antagonist of the Mu-type opioid receptor (OPRM1). Difenoxin is found in healthcare, pharmaceuticals, and veterinary products where it is used as an antipropulsive, with oral exposure as the recorded route. 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl- Difenossina [DCIT] difenoxin Difenoxin (USAN) Difenoxine Diphenoxin Diphenoxylic acid Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl- McN-JR 15,403-11 C28H28N2O2 424.544 424.215078 28782-42-5 OC(=O)C1(CCN(CCC(C#N)(C2=CC=CC=C2)C2=CC=CC=C2)CC1)C1=CC=CC=C1 InChI=1S/C28H28N2O2/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23/h1-15H,16-21H2,(H,31,32) UFIVBRCCIRTJTN-UHFFFAOYSA-N Detected and Not Quantified Difenoxin Drug Metabolism Action Pathway SMP0143772 Difenoxin Predicted Metabolism Pathway SMP0174848 logp 2.65 average_mass 424.544 ChemAxon mono_mass 424.215078 ChemAxon smiles OC(=O)C1(CCN(CCC(C#N)(C2=CC=CC=C2)C2=CC=CC=C2)CC1)C1=CC=CC=C1 ChemAxon formula C28H28N2O2 ChemAxon inchi InChI=1S/C28H28N2O2/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23/h1-15H,16-21H2,(H,31,32) ChemAxon inchikey UFIVBRCCIRTJTN-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7270663e80> DB01501 25273607 31620 BE0000770